肿瘤免疫治疗的目标是在淋巴器官中诱导产生肿瘤特异性 CD8 T淋巴细胞 （CTL细胞）并维持持久的抗肿瘤免疫应答以及增加浸润至肿瘤内部CTL细胞的数量。 而在诱导CTL免疫应答阶段，需要 树突状细胞 （DC细胞）负载肿瘤抗原并递呈至CTL细胞，该过程又离不开辅助性Th1 CD4 T细胞参与，这样才能保证产生足够有效力的CTL应答。 CD4 T细胞与CD8 T细胞的一个区别就是它们表面分别表达CD4分子和CD8分子（图1）。

2025年2月5日 · Fate-mapping and transfer experiments revealed that IFN-γ-expressing T helper (Th) 1 cells differentiated into Treg cells in response to TGF-β signaling in tumors. Pseudotime trajectory analysis further revealed the terminal differentiation of Th1 …

Th1 cells directly kill tumor cells via release of cytokines that activate death receptors on the tumor cell surface. We now know that cross-priming of the tumor-specific response by potent APC is a major mechanism of the developing endogenous immune response; therefore, even intracellular proteins can be presented in the context of MHC class II.

2019年3月1日 · In this study, we comprehensively investigated the potential roles of multiple CD4+ T cell cytokines (Th1, Th2, and Th17 cell cytokines) and Tregs as factors representing tumor status and...

2024年1月1日 · Polysaccharides can regulate the imbalance between Th1 and Th2 cells and their characteristic cytokine profiles, thereby improving the tumor immune microenvironment. To our knowledge, this study is the most comprehensive assessment of the regulation of the tumor Th1/Th2 balance by polysaccharides.

2021年11月1日 · Here, we investigated the effect of Th1 polarization in the tumor microenvironment (TME) on tumor-associated macrophage (TAM) maturation and activation. In our immunotherapy mouse model, with a Th1-dominant TME, tumors regressed in all cases, with complete regression in 80% of the cases.

To investigate the precise role of antigen-specific Th1 and Th2 cells in tumor immunity, we developed a novel adoptive tumor-immunotherapy model using OVA-specific Th1 and Th2 cells and an OVA gene-transfected tumor. This therapeutic model demonstrated that both antigen-specific Th1 and Th2 cells ha …

2011年3月15日 · Strikingly, successful cancer immunosurveillance mediated by tumour-specific CD4+ T cells is consistently associated with elevated local levels of both proinflammatory (IL-1α, IL-1β and IL-6 ...

Genetic deletion or monoclonal antibody–mediated neutralization of PF4 in tumor-bearing mice decreased T H 1-T regs in the TME, enhanced antitumor immunity, and suppressed tumor growth. This molecular pathway may open new avenues for cancer immunotherapy targeting tumor-associated macrophages and T regs within the TME. —Priscilla N. Kelly

2025年2月25日 · This subpopulation, absent in the thymus and peripherally induced, exhibits type 1 helper T cell (Th1)-poised characteristics and contributes to the inhibition of cancer progression in B16F10...