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    Nature
    https://www.nature.com › articles

    Transcription tipping points for T follicular helper cell and T-helper ...

    • During viral infection, immune cells coordinate the induction of inflammatory responses that clear infection and humoral responses that promote protection. CD4+ T-cell differentiation sits at the center of this axi… 展开

    Introduction

    CD4+ T cells form a bridge between the cell-mediated and humoral arms of the adaptive immune response to pathogens. Following infection, naive CD4+ T cells can differentiate into … 展开

    Nature
    The Bcl6–T-bet axis: the linchpin of Tfh/Th1 equilibrium

    Despite being phenotypically and functionally distinct, Tfh and Th1 cells share … 展开

    Nature
    Transcriptional networks of the Tfh/Th1 dichotomy: fine-tuning the lineage-defining factors

    High mobility group (HMG) transcription factors
    The interplay between multiple transcription factors is highly regulated and forms the backbone of T-c… 展开

    Nature
    Cytokine mediators of the Th1/Tfh dichotomy: translating inflammation into cell fate

    We recently reported the transcriptional heterogeneity that underlies the flexibility in Tfh differentiation in distinct viral infections.46 Specifically, T-bet is required in a context-dep… 展开

    Nature
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