In addition to reducing EAU-induced Th17 cell accumulation, KU also reduced the expression of some genes (Id2, Pim1, and Satb1), Th17 cell differentiation, and IL-17 signaling pathways. The inhibition of Id2 and Pim1 can reduce the differentiation of CD4 + T cells and the pathogenicity of Th17 cells . Our in vivo and in vitro experiments found ...

该研究将PIM1鉴定为EAU期间Th17/Treg细胞平衡、Th17细胞致病性和PC分化的重要调节因子。 PIM1/AKT/FOXO1信号可能是EAU发病机制的潜在机制，介导Th17细胞和Treg细胞之间的不平衡，研究者认为PIM1抑制可能会改善EAU。

2023年6月6日 · In the experimental autoimmune uveitis (EAU), an animal model mimicking human autoimmune uveitis 14, Th17 cells were found to be a predominantly pathogenic mediator in...

2024年3月8日 · CD4 + T细胞中的乳酸化水平随着实验性自身免疫性葡萄膜炎（EAU）的进展而增加。抑制乳酸化可抑制TH17分化并减轻EAU炎症。机制上，Ikzf1在Lys 164 处的高乳酸化通过直接调节TH17相关基因（包括Runx1、Tlr4、白细胞介素-2（IL-2）和IL-4）的表达，促进TH17的分化。

2024年3月28日 · 研究者通过构建实验性自身免疫性葡萄膜炎（Experimental autoimmune uveitis，EAU）动物模型，首次揭示PRG能用于治疗葡萄膜炎的可行性，并通过分析CDLNs的scRNA-seq数据，探讨了PRG对治疗AU的潜在分子机制。 作者首先发现PRG能改善EAU模型小鼠的视网膜病变和炎症浸润。 进一步通过单细胞测序数据分析发现，PRG可调节Th17/Treg失衡，逆转Id2/Pim1轴、IL-23/ Th17/GM-CSF信号的传导，减弱了Th17的致病性，进而减轻EAU的疾 …

2025年3月3日 · STING deficiency promotes the differentiation and phenotypic transformation of Th17-like Tfh cells, exacerbating the inflammatory response in EAU. These findings highlight the potential of targeting STING to modulate Tfh cells as a therapeutic s …

In Sting −/− EAU mice, disease severity and the infiltration of Th17-like Tfh and Th17 cells were found to be elevated, confirming the influence of STING on Tfh cells. Meaningfully, stimulating STING could suppress Th17-like Tfh and alleviate inflammation in EAU.

2008年4月14日 · Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. We examined the role of the interleukin (IL)-23-IL-17 and IL-12-T helper cell (Th)1 pathways in the pathogenesis of EAU. IL-23 but not IL-12 was necessary to elicit disease by immunization with the retinal antigen (Ag) in …

2024年3月25日 · Our study constructed a high-resolution atlas of the immunoregulatory effects of KU treatment on EAU and identified its potential therapeutic mechanisms, which hold great promise in treating autoimmune disorders.

2024年10月1日 · Our results showed that PM2.5 could exacerbate the activity of EAU, as evidenced by severer clinical and pathological changes, correlated with elevated Th17 cells frequency and IL-17A expression. Proteomic analysis revealed ferroptosis was the most significant pathway.