2019年3月7日 · Th17 cells provide protection at barrier tissues but may also contribute to immune pathology. The relevance and induction mechanisms of pathologic Th17 responses in humans are poorly understood. Here, we identify the mucocutaneous pathobiont Candida albicans as the major direct inducer of human anti …

In this review we will discuss CLRs and other relevant pattern recognition receptors (PRRs) in innate fungal recognition, and the subsequent activation of Th17-based adaptive immunity. We will focus on these responses primarily in the context of the most common and best-characterized human fungal pathogen, Candida albicans, although lessons ...

2019年3月15日 · Th17 cells are central orchestrators of immune responses against extracellular bacteria and fungi. They organize protective immunity at barrier sites, and as such, they are largely confined to intestinal tissues and the skin under …

2023年6月1日 · The lack of Th17-phenotype cells was confirmed functionally by demonstrating reductions in proportions of memory CD4 + T cells expressing intracellular IL-17A, IL-17F, and IL-22, 112 as well as abolished production of these canonical Th17 cytokines by purified memory CD4 + T cells in vitro under nonpolarizing conditions and by naïve and memory ...

protective intestinal Th17 responses against C. albi-cans and lung inflammation caused by airborne fungi. We identify heterologous immunity to a single, ubiquitous member of the microbiota as a central mechanism for systemic induction of human anti-fungal Th17 responses and as a potential risk factor for pulmonary inflammatory diseases ...

The progressive molecular and cellular description of inborn errors of immunity (IEI) with syndromic CMC pointed toward a possible role of IL-17-mediated immunity in protecting against fungal infection and CMC.

2012年5月17日 · Here, we discuss emerging fundamental discoveries with C. albicans that have informed our overall molecular understanding of fungal immunity. In particular, we focus on the importance of pattern recognition receptor-mediated fungal recognition and subsequent IL-17 responses in host defense against mucosal candidiasis.

2011年1月1日 · Although T H 1 responses driven by the IL-12/IFN-gamma axis are central to protection against fungi, the paradigm has been revisited with two new T cell populations entering the scene: the T H 17 cells involved in inflammatory responses, and the T regulatory cells (Tregs), which minimize immune responses to avoid damage to the host.

2020年7月27日 · Individuals with primary immunodeficiencies resulting in defective Th17 immunity, such as STAT3 loss-of-function (LOF) mutations in autosomal-dominant hyper-IgE syndrome, STAT1 gain-of-function...

2012年5月17日 · In this review, we will discuss CLRs and other relevant pattern recognition receptors (PRRs) in innate fungal recognition and the subsequent activation of Th17-based adaptive immunity. We will focus on these responses primarily in the context of the most common and best-characterized human fungal pathogen, Candida albicans , although lessons ...