Th17细胞是首个被确定有别于Th1/Th2模式的亚群，且基于IL-23刺激后IL-17A同型二聚体的表达。 Th17细胞生成另一个同型二聚体IL-17家族成员IL-17F，以及异质二聚体蛋白IL-17AF，IL-17AF由IL-17A的一个亚基和IL-17F的一个亚基组成。 IL-17介导的反应在上皮细胞、内皮细胞和成纤维细胞中最具特征，这些细胞通过分泌TNFα、IL-1β、IL-6、IL-8、CXCL1、CXCL8和G-CSF来应答IL-17R信号，从而促进中性粒细胞募集和炎症反应。 细胞因子IL-22是IL-10家族成员之一，研究 …

Here, I summarize our current knowledge of the unique gene expression, cytokine-mediated regulation and transcriptional programming of TH17 cells, and provide my personal perspectives on the ...

2016年6月1日 · Interleukin-17 (IL-17)-producing T helper cells (Th17 cells) constitute a lineage of CD4 effector T helper cells that is distinct from the Th1 and Th2 CD4 phenotypes. In humans, Th17 differentiation is induced in the presence of the cytokines IL-1 beta, IL-6 and TGF beta, whereas IL-23 maintains Th1 …

2021年5月21日 · To exhaustively investigate the differentiation process of human Th17 cells, we performed a genome-wide transcriptome analysis of naive CD4+ T cells (Figure S1) differentiated under Th17 conditions, IL-1β, IL-6, transforming growth factor (TGF)-β, and IL-23, compared with unpolarized cells (Th0).

The aim of the present study was to find new markers of Th17 cells that could be of clinical relevance to identify inflammation caused by these lymphocytes. Using a transcriptomic approach, we selected several candidate genes, the expression of which at the mRNA and protein levels was then analyzed in Th1, Th2, Th17, and Treg cells.

2015年12月15日 · The T helper 17 (Th17) cell pathway has been linked by genome-wide association studies to multiple autoimmune diseases. Identification of the genetic causes of primary immunodeficiency diseases revealed that Th17 cells are also critical in host immunity to mucocutaneous candida infections and Staphylococcus aureus.

Th17 cells are a lineage of CD4+ T helper cells with Th17-specific transcription factors RORγt and RoRα. Since its discovery in 2005, research on Th17 has been in rapid progress, and increasing cytokines or transcription factors have been uncovered in the activation and differentiation of …

2008年4月11日 · The characterization of the new lineage of IL-17-producing CD4+ T helper (Th17) cells has revolutionized our current understanding of T cell-mediated immunity. Over the past five years, there have been many twists and turns as the pathways that lead to Th17 cell differentiation have been elucidated.

2017年11月17日 · Assessing 15 representative signature genes in patients with multiple sclerosis, we find that T H 1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and...

2011年12月12日 · We report that Th17 cells, despite displaying low expression of CD27 and other phenotypic markers of terminal differentiation, efficiently eradicated tumors and caused autoimmunity, were long-lived and maintained a core molecular signature resembling early memory CD8 + cells with stem cell-like properties.