IL-1R1 signaling induces human Th17 cell differentiation, leading to the expression of IL-1R-associated protein kinase (IRAK)4 and retinoic acid-related orphan nuclear hormone receptor (ROR), Th17 cell lineage transcription factors, which together with signal transducer and activator of the transcription (STAT)3, activate this cell lineage's ...

A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases. The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. T-bet represses T (H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat.

Here we show that IL-1R1 expression in T cells, which was induced by IL-6, was necessary for Th17-mediated autoimmunity and for early Th17 differentiation in vivo. Moreover, IL-1 signaling in T cells was required in dendritic cell-mediated Th17 differentiation from naïve or regulatory precursors and IL-1 synergized with IL-6 and IL-23 to ...

2024年4月9日 · Using a combination of genetic models and antibody depletion studies, we demonstrated a role for IL-1-related cytokines in Th17 TRM cell generation following immunization with OmpX + LTA1. In...

2009年4月17日 · IL-1R1 signal was required for the early differentiation of Th17 cells and conversion of Foxp3 + T cells into IL-17-producing cells. After polarization, IL-1 also allowed Th17 cells to maintain their cytokine secretion profile. The IL-1R1 signaling in T cells functioned by upregulating IRF4 and RORγt.

2016年11月28日 · IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naive and memory CD4 + T cells derived from relapsing-remitting multiple sclerosis (RR MS) patients in …

2024年6月7日 · Th17 cells are identified by the cell surface markers cluster of differentiation (CD)161, chemokine receptor (CCR)6, CCR4, interleukin receptor (IL)-23R, and IL-1R, the lineage-defining...

2016年6月21日 · Foxo1 negatively regulated the pathogenicity of Th17 cells in part by inhibiting expression of cytokine receptor IL-1R1. These findings indicate that the miR-183C drives Th17 pathogenicity in autoimmune diseases via inhibition of Foxo1 and …

2025年3月14日 · 此外，Th17细胞在I型糖尿病中也具有致病作用，Th17细胞在1型糖尿病患者的血液中扩增，IL-17增强人类胰岛细胞的炎症反应。用抗IL-17单克隆抗体或重组IL-25（抑制Th17细胞）治疗可减轻疾病。抗IL-12p40和抗IL-17单克隆抗体的临床试验正在1型糖尿病病人中进行。

IL-1R1 signaling induces human Th17 cell diferentiation, leading to the expression of IL-1R-associated protein kinase (IRAK)4 and retinoic acid-related orphan nuclear hormone receptor (ROR), Th17 cell lineage transcription factors, which together with signal transducer and activator of the transcription (STAT)3, activate this cell lineage’s spec...