Membrane-bound IL-6R is upregulated on Th17 cells and inhibits …
2021年12月16日 · Our analysis shows that membrane-bound IL-6R is upregulated on Th17 cells and is inversely correlated with IL-6 serum levels in experimental autoimmune arthritis. …
Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell …
2020年9月15日 · IL-6R and IL-23R are key players in the development and maintenance of Th17 cells 19. A recent study demonstrated increased percentage of CD4 + T cells expressing IL …
Th17 Cells Require Ongoing Classic IL-6 Receptor Signaling to …
We find that expression of IL-6Rα by mature Th17 cells is indispensable for maintenance of the Th17 phenotype and a pathogenic response. Classic IL-6 receptor signaling was dominant …
Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 …
2025年1月23日 · Notably, we identify a novel mechanism whereby DYRK1A regulates response to IL-6, the key driver of Th17 differentiation, in part by regulating surface levels of gp130 and …
Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell …
2020年9月15日 · Because proliferation of M. leprae antigen-specific Th17 cells depend on TCR engagement with high IL-6R expression and is correlated with specific IL-17A response in our …
Membrane-bound IL-6R is upregulated on Th17 cells and
2021年12月16日 · Our analysis shows that membrane-bound IL-6R is upregulated on Th17 cells and is inversely correlated with IL-6 serum levels in experimental autoimmune arthritis. …
Human IL-6RhiTIGIT− CD4+ CD127lowCD25+ T cells
2017年6月1日 · We identified a subset of circulating IL-6R hi TIGIT − CD127 low CD25 + T cells (designated as IL-6R hi TIGIT − mTregs) with a Th17 transcriptional profile, marked by the …
膜结合的 IL-6R 在 Th17 细胞上上调，并通过调节自身免疫性关节 …
在这项研究中，我们通过流式细胞术评估了在胶原诱导的关节炎 (CIA) 发展过程中 Th17 细胞上膜结合 IL-6 受体 (IL6R) 表达水平的动态变化。 在下一步中，进行了基于蛋白质组学的生物信息 …
IL-6 fuels durable memory for Th17 cell-mediated responses to …
IL-6 modulated the balance between Th17 and Treg cells to promote the superior antitumor responses of Day 4 Th17 cells. Herein, we describe how a shortened T cell expansion protocol …
Elevated IL-6R on CD4 + T cells promotes IL-6 driven Th17 cell ...
2020年9月15日 · The present study for the first time establishes that pathogenic Th17 cells produce IL-17 in an IL-6 dependent manner in leprosy T1R reactions. Thus, present …