Gamma butyrolactone (GBL) is a chemical in cleaning solutions and nail polish. In the body, GBL is converted to gamma-hydroxybutyrate (GHB), a date- rape drug. When the body converts GBL into...

γ-Butyrolactone (GBL) or gamma-butyrolactone is an organic compound with the formula O=CO (CH2)3. It is a hygroscopic, colorless, water-miscible liquid with a weak characteristic odor. It is the simplest 4-carbon lactone. It is mainly used as an intermediate in the production of other chemicals, such as N-methyl-2-pyrrolidone. [5]

GBL (gamma-butyrolactone) and GHB (gamma-hydroxybutyrate) are both central nervous system depressants that are commonly used as recreational drugs. GBL is a prodrug of GHB, meaning it is converted into GHB once ingested. Both substances have similar effects, including euphoria, relaxation, and sedation.

γ-丁内酯（英語： gamma-Butyrolactone ，簡稱GBL）是一种易潮解的无色油状液体，有较弱的特征气味并且能溶于水。 γ-丁内酯是化学中的一个常见 溶剂 和 反应试剂 ，它也被用作一种 芳香物 、 去污剂 、 氰基丙烯酸酯 去除剂、 除漆剂 以及一些液体铝 电解电容器 ...

2023年5月1日 · Gamma-Butyrolactone (GBL) is an organic compound with the chemical formula C₄H₆O₂, also known as gamma-hydroxybutyrate (GHB) or 4-hydroxybutyric acid lactone. It is a colorless, odorless compound with a pleasant sweet taste. GBL is a naturally occurring compound that certain plants, fungi, and bacteria produce.

2022年5月16日 · GBL is a very dangerous drug that is highly addictive and can cause GBL drug overdose, as the difference between a GBL drug overdose and a recreational dose is really small. GBL is also used as a ‘date rape’ drug and people can become physically dependent on the drug and need a medically assisted detox to safely stop using.

Gamma butyrolactone is a chemical. People use it as medicine. Be careful not to confuse gamma butyrolactone (GBL) with gamma hydroxybutyrate (GHB). Despite serious safety concerns and illegality, people take gamma butyrolactone for improving athletic performance, sleep, and sexual performance and pleasure.

在有机合成中，gbl也有广泛的用途，它是合成α-吡咯烷酮、n-甲基吡咯烷酮、乙烯基吡咯烷酮、乙酰基-γ-丁内酯、环丙胺等的原料，是合成杀虫剂、除草剂、药物脑复康、环丙氟哌酸、维生素b1，叶绿素等的中间体。

Gamma-butyrolactone (GBL) is an industrial chemical, and is illicitly used as a substitute and chemical precursor to gamma-hydroxybutyric acid (GHB). GBL and 1,4-butadiene (BD) are structurally similar to GHB and there is evidence to confirm that GBL and BD are converted to GHB after oral administration. GHB is a schedule I depressant.

γ-丁內酯（英語： gamma-Butyrolactone ，簡稱GBL）是一種易潮解的無色油狀液體，有較弱的特徵氣味並且能溶於水。 γ-丁內酯是化學中的一個常見 溶劑 和 反應試劑 ，它也被用作一種 芳香物 、 去污劑 、 氰基丙烯酸酯 去除劑、 除漆劑 以及一些液體鋁 電解電容器 ...

In support of this view, we describe a clinical case of difficult to manage GBL withdrawal symptoms in a 42-year-old male. We also review the literature on treatment options for GBL/GHB withdrawal, including benzodiazepine-resistant withdrawal.

γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。 在有机合成中，GBL也有广泛的用途，它是合成α-吡咯烷酮、N-甲基吡咯烷酮、乙烯基吡咯烷酮、乙酰基-γ-丁内酯、环丙胺等的原料，是合成杀虫剂、除草剂、药物脑复康、环丙氟哌酸、维生素B1，叶绿素等的中间体。 还用于合成氯苯氧基丁酸类除莠剂，植物生长调节剂 …

GBL and 1,4-BD are turned into GHB in your body after you take them. All three have different dosages - and just a millilitre can be the difference between overdosing or not. GBL comes on faster than GHB and is stronger, meaning it's easier to overdose on than GHB; 1,4-BD has a slower onset than GHB but can be more potent.

Gamma-butyrolactone (GBL) is a precursor in the manufacture of gamma-hydroxybutyric acid (GHB). In In aqueous solution, GBL undergoes a hydrolysis reaction and exists in equilibrium with GHB.

During the last few years γ-hydroxybutyric acid (GHB) and γ-butyrolactone (GBL) have attracted much interest as recreational drugs and knock-out drops in drug-facilitated sexual assaults. This experiment aims at getting an insight into the pharmacokinetics of GHB after intake of GBL.

2025年1月10日 · The findings underscore the need for comprehensive and integrative prevention and treatment strategies for GHB/GBL/BD use, with harm reduction approaches prioritized over restrictions. They provide a crucial foundation for future research and interventions and emphasize the necessity of adequately addressing the growing issues related to GHB ...

Gamma-butyrolactone is a butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2. It has a role as a neurotoxin and a metabolite. One of the furans with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate.

Gamma-butyrolactone (GBL) is a small, lipophilic molecule that readily absorbs in the body when consumed orally. In vitro, GBL and gamma-hydroxybutyrate (GHB) are subject to interconversion depending on the pH (1). In vivo, GBL is a precursor to GHB, an endogenous chemical that is found in low concentrations in the body.

As the supply of GBL quickly diminishes, the desire to find a synthesis of GBL from tetrahydrofuran (THF) increases. Just to make this a more thorough study, here are a few more ref's for a few more procedures worth looking at.

Gamma-butyrolactone (GBL) is rapidly metabolized to gamma-hydroxybutyrate (GHB) in vivo following ingestion. GBL and GHB cause similar clinical features in users, and both of these agents are widely used as recreational drugs due to their mood-enhancing, stimulant and prosexual effects, particularly on the nightclub scene. 1,2