Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome (aHUS).

2019年11月13日 · Thrombomodulin (THBD) is a transmembrane protein that regulates endothelial function by 1) binding thrombin and inhibiting its interaction with fibrinogen, 2) augmenting protein C activation, and 3) down-regulating complement activation by inactivating C3a and C5a (PMID 29866818).

2022年11月1日 · Our data suggest that endothelial specific BRG1 deficiency ameliorates THBD repression but does not alter TF expression in the presence of TNF-α in EA.hy926 cells, which indicates that BRG1 may possess a pro-thrombotic role by skewing the equilibrium of coagulation and anticoagulation via regulating the THBD expression in endothelial cells.

2024年12月28日 · THBD基因编码的蛋白叫做血栓调节蛋白（thrombomodulin），这种蛋白在血管内皮细胞表面大量表达。 它的主要功能是调节血液凝固过程，防止血栓的过度形成。

2024年12月25日 · THBD (Thrombomodulin) is a Protein Coding gene. Diseases associated with THBD include Thrombophilia Due To Thrombomodulin Defect and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Diseases …

2023年5月16日 · 该研究确定血栓调节蛋白（thbd）信号传导是衰老细胞命运的关键分子决定因素。 尽管THBD通常仅限于内皮细胞，但在衰老哺乳动物组织和衰老细胞模型中，THBD在衰老程序的所有阶段都会迅速上调并维持。

本文总结了hPSC衍生细胞分离过程的最新进展，包括标准的分离技术，如磁激活细胞分选，以及基于粘附强度和代谢通量等新型分离策略。

2022年3月3日 · Thrombomodulin (THBD) is a transmembrane protein that functions at the luminal surface of vascular endothelial cells to bind thrombin and inhibit its interaction with fibrinogen, augment protein C activation, and down-regulate complement activation. 2 Oxidative stress can reduce THBD function by inducing extracellular proteolytic cleavage of ...

2022年1月5日 · 尽管几项研究已经在静脉血栓栓塞 (VTE)患者中发现了血栓调节蛋白基因 (THBD)变异，但THBD在VTE患者中的作用仍有待阐明。 近日，血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章，该研究旨在明确大型中老年人群中罕见和常见THBD变异个体的血栓形成风险。 研究人员对参与马尔默饮食与癌症研究 (1991-1996)的28794名受试者（出生于1923-1950年，60%为女性）的THBD外显子组序列进行了合格突变 …

2021年7月9日 · We investigated how signaling by coagulation proteases affects the quality and extent of the response to the TLR3-ligand poly (I:C) in human endothelial cells. Genome-wide RNA profiling documented additive and synergistic effects of thrombin and poly (I:C) on the expression level of many genes.