The history of mass spectrometry has its roots in physical and chemical studies regarding the nature of matter. The study of gas discharges in the mid 19th century led to the discovery of anode and cathode rays , which turned out to be positive ions and electrons .

2008年7月31日 · Thomson’s early work on cathode rays laid the foundation of the MS field. Ultimately, Thomson, with the help of his protégé Francis Aston (who would go on to win his own Nobel Prize in Chemistry in 1922), built what later would be recognized as the first mass spectrometer to measure the masses of charged atoms. This instrument used gas ...

2019年10月1日 · This year, it’s 100 years since Aston built his first mass spectrograph, a device capable of measuring the relative masses of individual atoms and molecules. His spectrograph, together with the findings he made with it, was to win him the 1922 Nobel Prize in Chemistry and launch the field of mass spectrometry.

First pre-packaged Magnetic Sector mass spectrometer with Helium enrichment jet separator by Ragnar Ryhage of the Karolinska Institute, sold by LKB INSTRUMENTS. 1964 GC/MS designed and built by Ragnar Ryhage of the KAROLINSKA INSTITUTE in Stockholm, Sweden.

2013年9月1日 · The first experiments in mass spectrometry were made 1898 by Wien [61], later successor of Conrad Röntgen at the University of Würzburg, who studied the nature of the anode rays in a Crookes tube.

In the first, a mass spectrometer was the experiment; instead of an integrated unit, an instrument used to do work defined in other terms, it was the arrangement of equipment composing essentially the whole experiment. Successful experiments provided particular results, but also demonstrated that apparatus of this design could be made to work.

2022年10月3日 · When ions with different charge/mass ratios coexisted in the particle stream, they were steered into a sequence of roughly parallel curves on the detecting medium creating what became known as a mass spectrum. When Aston and Thomson put neon gas into this instrument in 1912, they expected to see lines representing the ions Ne + and Ne 2+.

2013年9月9日 · The origins of mass spectrometry began with the earliest gas discharge experiments. These were conducted in a partially evacuated glass envelope in which electrodes were inserted. At an appropriate gas pressure and voltage across the electrodes, a variety of glowing light phenomena were observed.

2013年9月1日 · Thomson‘s positive-ray parabola apparatus was the first to have identifiable mass spectral lines and later incorporated some form of electronic detection for the ion current. Aston's and Dempster's mass spectrometers bear an even stronger resemblance to modern instruments.

In 1918, Arthur Jeffrey Dempster developed the first modern mass spectrometer, which was over 100 times more accurate than previous versions, and established the basic theory and design of mass spectrometers that is still used to this day.