The authors compared prefrontal cortex function in anxious and healthy adolescents and adults following conditioning and extinction, processes requiring threat-safety learning. Method: Anxious and healthy adolescents and adults (N=114) completed fear conditioning and extinction in …

2013年10月1日 · The current fMRI paradigm was explicitly designed to capture precisely the transitional boundary between threat and safety through the use of morphed images (17 – 19) (Figure 1). In blocks of trials, participants viewed the CS+ and CS− and nine morphed images consisting of different blends of the CS− and CS+.

2024年2月20日 · Combining an uncertainty-variation threat anticipation paradigm that allows precise modulation of the level of momentary anxious arousal during functional magnetic resonance imaging (fMRI) with...

2024年3月28日 · In order to memorize and discriminate threatening and safe stimuli, the processing of the actual absence of threat seems crucial. Here, we measured brain activity with fMRI in response to both...

2021年11月17日 · These findings provide the first evidence for separable whole-brain fMRI multivariate patterns for subjective experience of fear and conditioned threat, indicating functionally independent...

2021年1月15日 · The goal of the present study was to therefore examine the shared and unique neural correlates of temporally unpredictable threat and reward processing in a sample of young adults using fMRI variants of the well-validated NPU paradigm, in which temporal unpredictability of threat (i.e. mild electric shock) and reward (i.e. monetary incentive ...

2020年12月1日 · This is the first fMRI study to investigate differential threat and safety reversal learning in young, unmedicated patients with SAD. Our findings replicate previous studies that implicate key regions within the ‘extended fear network’ as central to successful threat-safety reversal learning (Apergis-Schoute et al., 2017; Savage et al ...

We aimed to characterize the neural, subjective, and autonomic correlates of reversal learning in patients with SAD and compare them to matched patients with major depressive disorder and to healthy control participants. All participants completed a threat-safety reversal learning task during functional magnetic resonance imaging.

In the MRI scanner, two key findings emerged during events that required participants make difficult threat-safety discriminations when appraising threat. First, relative to healthy individuals, anxious adults and adolescents both exhibited hypo-activation in the sgACC, suggesting the presence of a shared feature in adult and adolescent anxiety ...

We report on two functional magnetic resonance imaging (fMRI) studies, one employing prolonged presentations (2s) of threat-gaze pairs to allow for reflective processing (Study 1), and one employing severely restricted (33 ms), backward masked presentations of threat-gaze pairs to isolate reflexive neural responding (Study 2).