2024年10月2日 · The thyrotropin receptor antibody (TRAb) test is a blood test that helps healthcare providers diagnose the autoimmune thyroid condition called Graves' Disease. The antibodies it tests for are present in between 90% and 100% of the people who have this disease.

Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves' disease, and is the cause of the hyperthyroidism of that condition.

These autoantibodies, also known as long-acting-thyroid-stimulators or thyroid-stimulating immunoglobulins (TSI), bind to the receptor and transactivate it, leading to stimulation of the thyroid gland independent of the normal feedback-regulated thyrotropin stimulation.

The Roche TSH/thyrotropin receptor antibody (TRAb) assay is a competitive assay using electrochemiluminescence detection. Patient sample is treated with a reagent buffer consisting of a pre-formed immunocomplex of solubilized porcine thyrotropin (TSH) receptor and biotinylated anti-porcine TSH receptor mouse monoclonal antibody.

2017年8月28日 · There are four main types of thyroid antibodies: 1) thyroid peroxidase antibodies, 2) thyroglobulin antibodies, 3) thyroid stimulating immunoglobulins, and 4) thyrotropin-blocking antibodies. Since these antibodies are targeted against the body’s own proteins, they are often referred to as autoantibodies.

Thyroid antibodies develop when a person’s immune system mistakenly attacks the thyroid cells and tissues. This leads to inflammation, tissue damage or disrupted thyroid function. These antibodies cause autoimmune thyroid disorders, such …

TSH receptor antibody (TRAb) is considered the gold standard diagnostic test for the autoimmunity of Graves’ disease (GD), which is commonly diagnosed clinically. To evaluate the true positive (sensitivity) and true negative (specificity) rates of ...

Serum thyrotropin receptor stimulating antibodies (TSAb) bind to the TSHR which are expressed on the surface of genetically engineered cells. The activation leads to an increase of cyclic adenosine monophosphate (cAMP) production.

Thyrotropin (TSH) and thyrotropin receptor antibodies (TSH-R-Abs) bind to the TSH-R and activate signal transduction pathways that lead to activation of genes involved in thyroid cell growth and hormone production.

Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility.