Tiagabine, sold under the brand name Gabitril, is an anticonvulsant medication produced by Cephalon that is used in the treatment of epilepsy. The drug is also used off-label in the treatment of anxiety disorders including panic disorder.

2025年2月10日 · Tiagabine is an anti-epileptic medication, also called an anticonvulsant. Tiagabine is used in combination with other medications to treat partial seizures in adults and …

Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. The next evolution of DrugBank is here.

Tiagabine is used in combination with other medications to treat partial seizures (a type of epilepsy). Tiagabine is in a class of medications called anticonvulsants. It is not known exactly …

Tiagabine hydrochloride (TGB) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. TGB is effective as an add-on medication in adults and children 12 years and older in the treatment of partial seizures.

Tiagabine is a piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis (3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of …

To review current data regarding the mode of action, pharmacokinetics, clinical efficacy and tolerance of tiagabine (TGB). Development. TGB is a drug which boosts gabergic inhibition by blocking the re­uptake of synaptic GABA by the glia and neurones.

Introduction: Tiagabina (TGB) is a new anti-epileptic drug which inhibits the uptake of GABA by the neurons and glia and prolongs the time GABA remains at the synapse. Development: Experimental studies suggested the efficacy of TGB in generalized tonic-clonic crises, in focal crises and in myoclonic crises.

Tiagabine is a new antiepileptic drug which acts by blocking neuronal and glial GABA uptake and it is indicated in the treatment of partial epilepsies. Its pharmacokinetics is lineal, being extensively metabolized in the liver by means of CYP3A4 isoenzyme.

We analyze the most usual pharmacokinetic and pharmacodynamic characteristics of TGB, considering current therapeutic indications showing its increased use in seizures and partial epileptic syndromes.