TEK Gene - GeneCards | TIE2 Protein | TIE2 Antibody
2024年12月25日 · TEK is a gene that encodes a receptor tyrosine kinase that regulates angiogenesis and vascular stability. It is also known as TIE2, VMCM1, and CD202b, and is involved in venous malformations and glaucoma.
TEK tyrosine kinase - Wikipedia
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase.)
This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. TEK has also been suggested as a marke…Wikipedia · CC-BY-SA 许可下的文字- 预计阅读时间：5 分钟
ANG-TIE2轴：肿瘤免疫治疗绕不开的靶点 - 知乎 - 知乎专栏
本文介绍了ANG-TIE2轴在肿瘤血管生成和免疫调节中的作用，以及ANG2的多种功能和机制。文章还探讨了ANG2阻断剂在肿瘤免疫治疗中的潜在潜力和挑战。
- 癌症免疫治疗主要是增强或恢复患者免疫系统识别、杀伤肿瘤细胞的能力，但是肿瘤细胞很“狡 …
但是，血管生成涉及到多种细胞因子，如VEGF、TNF-α、血管生成素-1（ANG1，也称为ANGPT1）和ANG2（也称为ANGPT2）。越来越多的证据表明，血管生成素（Angiopoeitin，Ang）在肿瘤、血管相关性疾病中扮演着重要角色。在许多癌症类型中，ANG2 …
- 癌症免疫治疗主要是增强或恢复患者免疫系统识别、杀伤肿瘤细胞的能力，但是肿瘤细胞很“狡 …
Tie2: a journey from normal angiogenesis to cancer and beyond
The tyrosine kinase receptor Tie2 was initially identified as a specific vascular growth factor that governed several properties of endothelial cells under both physiological and pathological …
- 作者: V. Martin, D. Liu, J. Fueyo, C. Gomez-Manzano
- Publish Year: 2008
The angiopoietin receptor Tie2 is atheroprotective in arterial
2023年3月13日 · We show that deletion of Tie2, or both Tie2 and Tie1, in the arterial endothelium promotes atherosclerosis by increasing Foxo1 nuclear localization, endothelial adhesion …
TIE-2 (Angiopoietin-1 receptor, Tyrosine-protein kinase
TIE-2 (Angiopoietin-1 receptor, Tyrosine-protein kinase receptor TEK) The tyrosine kinase receptor TIE-2 was initially identified as a specific endothelial growth factor receptor that …
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Targeting Tie2 in the Tumor Microenvironment: From ... - PubMed
2021年11月16日 · The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in …
Tie1-Tie2 Interactions Mediate Functional Differences …
2010年3月12日 · Despite considerable similarity, experiments with Tie1- or Tie2-deficient mice highlight distinct functions for these receptors in vivo. The Tie2 receptor is further unique with respect to its structurally homologous ligands. …
TEK gene: MedlinePlus Genetics
The TEK gene (also called the TIE2 gene) provides instructions for making a protein called TEK receptor tyrosine kinase. Learn about this gene and related health conditions.
21687 - Gene ResultTek TEK receptor tyrosine kinase [ (house …
2025年2月19日 · The Tie2/Ang-1 signaling pathway plays a critical role in the maintenance of hematopoietic stem cells in a quiescent state in the bone marrow niche. Tie2 signaling has a …
