The Tigano Laboratory performs foundational research on mitochondrial disorders, mitochondrial DNA mutations, and mitochondrial stress signaling. With powerful genetic approaches and cutting-edge technologies, we aim to shed light on the complex signaling pathways that mitochondria use to communicate with the nucleus and other organelles about ...

In the lab, we perform foundational research to better understand aberrant mitochondrial signaling by defining its mechanistic aspects, triggering events, and propagation within cells and tissues. We use a wide gamut of genetic models, ranging from acute stress induced by mtDNA damage, inducible models of mtDNA deletions, and CRISPR ...

I am of the genus Andrew+ and I was born in 2021 in Geneve (Switzerland), from the experienced and CO2-neutral hands of Andrew Alliance. I joined the Tigano lab in 2021 as Assistant Robot (Junior).

Tigano M, Vargas DC, Tremblay-Belzile S, Fu Y, Sfeir A. Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance. Nature. 2021 Mar;591(7850):477-481. doi: 10.1038/s41586-021-03269-w. Epub 2021 Feb 24.

2021年2月24日 · Mitochondrial DNA double-strand breaks (mtDSBs) are toxic lesions that compromise the integrity of mitochondrial DNA (mtDNA) and alter mitochondrial function 1. Communication between mitochondria...

Ready to start planning your care? Call us at 833-347-1665 to make an appointment. PhD University of Parma (2012) View the Agnel Sfeir Lab page for Marco Tigano.

Marco Tigano, PhD Assistant Professor, Department of Pathology & Genomic Medicine Email Marco Tigano 215-503-8558

In the lab, we perform foundational research to better understand aberrant mitochondrial signaling by defining its mechanistic aspects, triggering events, and propagation within cells and tissues. We use a wide gamut of genetic models, ranging from acute stress induced by mtDNA damage, inducible models of mtDNA deletions, and CRISPR ...

Marco Tigano Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective...