2024年1月5日 · In vivo, cordycepin plus anti-TIGIT treatment significantly reduced the development rate of the CT26/MC38 mouse colon cancer model and increased the mice's …

We compared the tumor volumes of subcutaneous MC38 tumors on untreated TIGIT KO mice with those on WT mice treated with anti-TIGIT:mIgG2a antibody. We also included age, …

Sui and colleagues developed bispecific antibodies (bsAbs) targeting CD25 and TIGIT by leveraging the abundance of immune-suppressive CD25+ TIGIT+ double-positive regulatory T …

2022年7月6日 · Our study demonstrated TIGIT blockade can synergistically enhance anti-tumor T cell responses to RT via CD8 + T cells (dependent on CD103 + DCs), suggesting the clinical …

Here, we elucidate the anti-tumor activity of an Fc-silent anti-TIGIT antibody, identify target cell populations across cancer indications for PD-1 and TIGIT dual blockade, and characterize the …

2018年11月29日 · Therefore, the antibody-mediated TIGIT blockade could inhibit MC38 tumor growth through blocking TIGIT expressed on tumor cells. Taken together, our study for the first …

2015年9月28日 · We examined TIGIT-mediated immune regulation in different murine cancer models and determined that TIGIT marks the most dysfunctional subset of CD8 + T cells in …

Anti-tumor efficacy and pharmacodynamic changes were assessed using tool Fc-silent or Fc-enabled anti-mouse TIGIT antibodies in the MC38 tumor model. The ability of human TIGIT …

Anti-TIGIT facilitates potent anti-tumor immune response in multiple mouse tumor models. Anti-TIGIT potentiates tumor antigen-specific T-cell IFN-g production and increases T cell …

2022年3月7日 · Results: The expression of TIGIT in various immune cells was up-regulated after MWA, and the addition of TIGIT blockade to MWA prolonged survival and delayed tumor …