TimML is a Python package for the modeling of steady-state multi-layer groundwater flow with analytic elements. TimML may be applied to an arbitrary number of layers and an arbitrary sequence of aquifers and leaky layers. The head, flow, and leakage between aquifer layers may be computed analytically at any point in the aquifer system.

TimML is a computer program for the modeling of steady-state multi-layer flow with analytic elements and consists of a library of Python scripts and FORTRAN extensions. TimML may be applied to an arbitrary number of aquifers and leaky layers.

The model instance is stored in the variable ml. Next, three elements are added to the model: a well ( Well ), a reference point with a fixed head ( Constant ), and uniform flow ( Uflow ). The well is screened in the middle aquifer layer (which is number 1).

2016年3月24日 · ArcTim is a GIS based interface for TimML, a multi-aquifer analytic element model (AEM). AEMs have been used by many different entities to evaluate groundwater systems and groundwater/surface water interactions.

I am an Associate Professor of Electrical Engineering and Computer Science in MIT's Computer Science and Artificial Intelligence Laboratory (CSAIL), founding co-director of the Data System and AI Lab (DSAIL) at MIT, and co-founder of einblick analytics, inc.

Mark Bakker. An analytic element approach for modeling polygonal inhomogeneities in multi-aquifer systems. Advances in Water Resources, 29:1546–1555, October 2006 ...

ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell.

2023年11月20日 · 研究团队发现， ML-T7不仅能提高自然杀伤细胞的杀伤活性，还通过作用于TIM-3和TIM-4，促进树突状细胞的成熟和提升其抗原呈递能力。 利用多种原发性 肝细胞 癌小鼠模型，他们对ML-T7的治疗效果进行观察。 结果显示，与对照组相比，每两天腹腔注射一次20mg/kg或50mg/kg剂量的ML-T7治疗， 能够显著抑制肿瘤生长，并延长小鼠生存时间，减轻肿瘤微环境的免疫抑制性。 进一步研究表明， 20mg/kg ML-T7单独治疗与100mg/kg PD-1抑制剂 …

2023年11月23日 · 腹腔注射 ml-t7 在小鼠中具有良好的耐受性，不仅可以直接抑制肿瘤进展，还可以增强抗 pd-1 诱导的抗肿瘤反应。 该研究强调了小分子 tim-3 抑制剂 ml-t7 作为肿瘤免疫治疗有前途的工具的潜力。

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