TIM-3 is a promising target to selectively kill acute myeloid ... - PubMed
2010年12月3日 · Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target for AML. Here we identified T cell immunoglobulin mucin …
TIM-3靶点科普_机制原理&研究进展 - 知乎
TIM-3（T细胞免疫球蛋白粘蛋白-3，又称 CD366 、HAVCR2）是一种 负调控的免疫检查点蛋白。 表达于CD4+T细胞亚群（Th1/Th17细胞）调节性T细胞 (Tregs)、 CD8+T细胞 亚群 (Tc1)以及 …
One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid …
T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds …
TIM-3 Is a Novel Therapeutic Target for Eradicating Acute …
In a xenogeneic transplantation system, we showed that targeting of TIM-3 by an anti-TIM-3 cytotoxic antibody is sufficient to eradicate human AML LSCs without affecting normal human …
Anti-TIM3 chimeric antigen receptor-natural killer cells …
2024年7月11日 · The established CAR-TIM3 NK-92 cells effectively targeted TIM3 and displayed potent anti-tumor activity against various primitive AML cells, subsequently causing a …
Split CAR-T Cells Targeting CD312 and TIM-3 for AML to Reduce …
2024年11月5日 · The split CAR-T cells targeting CD312 and TIM-3 exhibit potential as a promising and secure therapeutic approach for patients with refractory and relapsed AML, …
Tim--3在AML白血病细胞和T细胞中的预后意义及生物学功能-学位 …
Caixia Li等发现Tim-3在NCCN高危组AML中CD8+T细胞高表达，提示Tim-3或许和患者不良预后具有一定相关性。 另一方面，Tim-3可通过影响TCF1的表达抑制T细胞增殖，阻断免疫检查点能 …
TIM-3 as a novel therapeutic target for eradicating acute
2013年9月18日 · In xenograft models reconstituted with human AML LSCs or HSCs, an anti-human TIM-3 mouse IgG2a antibody with cytotoxic activities eradicates AML LSCs in vivo, but …
Effective Killing of Acute Myeloid Leukemia by TIM-3 Targeted …
Our anti-TIM-3 CAR T cells exhibit potent antileukemic activity against AML cell lines and primary AML blasts, and in the mouse models. More importantly, we demonstrate efficient killing of the …
TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid …
2010年12月3日 · Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target for AML. Here we identified T cell immunoglobulin mucin …