2012年5月1日 · Thus, Tim3/Gal9, via IL-1β and downstream TNF production lead to apoptosis and restriction of intracellular Mtb growth. We propose that Tim3/Gal9 interaction acts as a …

2010年10月10日 · These data indicate that Tim3–Gal9 interaction leads to killing of Mtb independently of IFN-γ receptor signaling and iNOS production and strongly suggest that Tim3 …

3 天之前 · For example, in Mtb infection TIM3 could mediate activation against galectin-9-expressing macrophages 51. Thus, further studies are needed to determine its role in the …

2016年3月11日 · Given the important role of TIM3 in mediating T cell exhaustion during chronic viral infections, we determined whether TIM3 regulates T cell function during tuberculosis. We …

2022年1月25日 · In line with the animal studies, elevated TIM3 expression leads to decreased IFNγ production of CD8 + T cells in patients with active/severe Mtb infection, which can be …

Here, we reported an intriguing case of Mycobacterium tuberculosis (Mtb) infection that was characterized by persistent overexpression of TIM3 on circulating T cells and ongoing kidney …

We found that in Mtb infected Mϕ, Tim3 activates a program of antimicrobial immunity that involves the initial secretion of IL-1β followed by IL-1β mediated recruitment of other …

T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain …

The ability of pathogenic Mycobacterium tuberculosis (Mtb) to adapt to the hostile intracellu-lar environment of the macrophage has been in-strumental to its success as a pathogen. Host re …

Tim-3 has gained prominence as a potential candidate for cancer immunotherapy, where it has been shown that in vivo blockade of Tim-3 with other check-point inhibitors enhances anti …