TIM3 comes of age as an inhibitory receptor - Nature
2019年11月1日 · Recent studies have shown that TIM3 is part of a module that contains multiple co-inhibitory receptors (checkpoint receptors), which are co-expressed and co-regulated on …
TIM-3 polymorphisms in type 1 diabetes families
2008年6月1日 · We investigated the role of the rs10515746 (A/C), rs1036199 (A/C), and rs10053538 (A/C) single nucleotide polymorphisms (SNPs) within the TIM-3 gene in 186 …
TIM-3 restrains anti-tumour immunity by regulating ... - Nature
2021年6月9日 · Here, using conditional knockouts of TIM-3 together with single-cell RNA sequencing, we demonstrate the singular importance of TIM-3 on dendritic cells (DCs), …
TIM-3: An update on immunotherapy - ScienceDirect
2021年10月1日 · Some researchers have identified several single nucleotide polymorphisms (SNPs) in the TIM-3 gene, analyzed the TIM-3 genotype of RA, and found that the SNP …
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation
2024年2月13日 · Here, we discuss the distinct functions of LAG-3, TIM-3, and TIGIT, including their contributions to the regulation of immune cells beyond T cells, their roles in disease, and …
TIM-3 Rs10515746 (A/C) and Rs10053538 (C/A) Gene Polymorphisms …
In humans, several single nucleotide polymorphisms (SNPs) have been identified in the TIM-3 gene and are associated with inflammatory diseases. The aim of this study was to analyze the …
Tim-3: A co-receptor with diverse roles in T cell exhaustion and ...
2019年4月1日 · Tim-3 is characterized by 1) a conserved extracellular IgV domain with N-linked glycosylation sites, and a mucin-like stalk that contains O-linked glycosylation sites; 2) a …
Association between TIM-3 polymorphisms and cancer risk: a …
Single nucleotide polymorphisms (SNPs) of T-cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) were reported to individually associate with cancer risk. To further verify its …
Unravelling the potential of TIM-3 gene polymorphism in …
2024年8月1日 · Understanding the role of TIM-3 in hematopoietic stem cell transplantation (HSCT) may improve transplant outcomes. Our study evaluated the potential association …
Tim-3: An Activation Marker and Activation Limiter of Innate …
In this review, we focus on the expression and function of Tim-3 on innate immune cells and discuss (1) how Tim-3 is expressed and regulated on different innate immune cells; (2) how it …