2024年12月25日 · TIMP3 (TIMP Metallopeptidase Inhibitor 3) is a Protein Coding gene. Diseases associated with TIMP3 include Sorsby Fundus Dystrophy and Fundus Dystrophy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. [5] [6] This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM).

Timp-3TIMP一3是一种分子量为24 kD的非可溶性分泌型蛋白，只存在于细胞外基质中，对基质金属蛋白酶 (MMPs)有特异性的抑制作用，通过以1：1非共价结合的形式与MMPs结合，使MMPs失活，从而保护细胞外基质不被MMPs降解和重塑，. 1）TIMP-3对机体脏器有保护性作用，可以处理各种生物活性分子如细胞表面受体,趋化因子和细胞因子。 能够降解各种细胞外基质蛋白质，在许多细胞生理过程中扮演重要作用,如细胞增殖、迁移、分化、血管生成、细胞凋亡,与宿主防 …

TIMPs是一种内源性蛋白酶抑制剂，与基质金属蛋白酶（MMPs）以1:1结合形成复合物，调控MMPs的活化或功能。 人类中有4个TIMPs。 TIMP-1于1981年纯化，TIMP-2于1990年被克隆，TIMP-3于1992年被克隆，TIMP-4于1996被鉴定。 由184到194个氨基酸组成。 分为N端和C端结构域，每个结构域都有三个二硫键。 N末端结构域有时被称为“抑制结构域”，因为单独这个结构域也能够抑制MMPs。 然而，完整TIMP与MMPs的相互作用跨越两个结构域，可产生高一个数 …

Here, we provide an overview of TIMP3 gene structure, transcriptional and post-transcriptional regulators (transcription factors and microRNAs), protein structure and partners, its role in cardiovascular pathology and its application as therapy, while also drawing reference from TIMP3 function in other diseases.

2003年3月24日 · In this study we demonstrate the ability of TIMP3 to inhibit vascular endothelial factor (VEGF)–mediated angiogenesis and identify the potential mechanism by which this occurs: TIMP3 blocks the...

TIMP3 methylation is a marker for TN tumours and furthermore we showed for the first time that TIMP3 promoter methylation is an epigenetic marker of BRCA1ness tumours. As a novel CLOCK-dependent diurnal gene, TIMP3 inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes.

2020年6月16日 · Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that includes matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAM with thrombospondin mo …

Tissue inhibitor of metalloproteinases-3 (TIMP3) is vital in regulating several biological processes. TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent and MMP-independent pathways. Due to promoter methylation and miRNA binding, TIMP3 expression has been observed to decrease in various cancers.

由该基因家族编码的蛋白质是基质金属蛋白酶的抑制剂，基质金属蛋白酶是一组参与细胞外基质 (ECM) 降解的肽酶。 该基因的表达是响应有丝分裂刺激而诱导的，并且这种含有 netrin 结构域的蛋白质定位于 ECM。 该基因的突变与常染色体显性遗传病索斯比氏眼底营养不良有关。 [RefSeq 提供，2008 年 7 月] This gene belongs to the TIMP gene family.