Titin is a large abundant protein of striated muscle. Titin's primary functions are to stabilize the thick filament, center it between the thin filaments, prevent overstretching of the sarcomere, and to recoil the sarcomere like a spring after it is stretched. [42]

肌联蛋白（英語： titin ，源自古希臘神話中的泰坦，形容其結構的巨大程度 [2] 。 又稱 connectin），又稱 肌巨蛋白 ，是 人体 中是由肌联蛋白基因（TTN）编码的 蛋白质 。

2004年2月20日 · Titin forms an intrasarcomeric filament that is usually viewed as a stable structural and mechanical component of the myocardium (for earlier reviews 1–6). Here, we discuss recent work that indicates that the titin filament is dynamic both in structure and function.

Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse signaling pathways, particularly in cardiomyocytes.

Titin (right) is shown in yellow, actin in blue, and myosin in red. Titin is the largest protein chain in your body, with more than 34,000 amino acids. This titanic protein acts like a big rubber band in our muscles. It is attached at one end to the Z-disk (shown here at the top in blue), which organizes the thin actin filaments.

2025年1月2日 · 由 TTN （titin 基因） 编码，titin 已成为心脏疾病的主要疾病位点。 在功能上，肌苷充当第三种肌丝类型，连接肌节 Z 盘和 M 带，并调节心肌被动僵硬和牵张感应。

2010年6月21日 · The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule.

Titin is a functionally pleiotropic protein with specific functions mediated by its unique regions. Proper sarcomere formation requires titin, as myosin uses it as a blueprint that determines the length of the thick filament (Tonino et al., 2017). Titin also contains spring-like domains that grant it …

Titin is a >3,000-kDa large filamentous protein of vertebrate-striated muscle; single titin molecules extend from the Z disc to the M line. In its I-band section, titin behaves extensibly and is responsible for myofibrillar-passive tension during stretch.

Titin, also known as connectin, is an elastic and approximately 3,6 MDalton large protein which assembles itself to protein filaments. It is made of more than 30000 amino acids and includes 320 protein domains and therefore is known as the largest human protein. It is a part of the sarcomere, the smallest functional unit in the striated muscles.