Toll-like receptor 3 - Wikipedia
TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common …
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in ...
Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)-domain-containing adaptor-inducing …
TLR3 Ligands | Synthetic dsRNA - InvivoGen
InvivoGen provides synthetic dsRNA-based agonists known to activate TLR3. Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a hallmark of viral replication, and triggers …
Regulation of the nucleic acid-sensing Toll-like receptors
2021年7月16日 · Five mammalian TLRs can be activated by nucleic acid ligands (referred to here as NA-sensing TLRs): TLR3 recognizes double-stranded RNA; TLR7, TLR8 and TLR13 …
TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
2022年11月12日 · Toll-like Receptor 3 (TLR3) initiates a potent anti-viral immune response by binding to double-stranded RNA ligands. Previous crystallographic studies showed...
Structures of the Toll-like Receptor Family and Its Ligand Complexes
2008年8月15日 · Hydrophobic ligands of TLR1, TLR2, and TLR4 interact with internal protein pockets. In contrast, dsRNA, a hydrophilic ligand, interacts with the solvent-exposed surface of …
Endogenous toll-like receptor ligands and their biological …
TLR3-deficiency or administration of anti-TLR3 antibody to wild-type mice protects these animals from hyperoxia-induced lung injury and inflammation in the absence of a viral pathogen, …
The TLR3 signaling complex forms by cooperative receptor ... - PNAS
2008年1月8日 · Here, we describe the mechanism by which TLR3 recognizes its ligand, double-stranded RNA (dsRNA), and forms an active signaling complex. We show that dsRNA binds …
Dimerization of Toll-like Receptor 3 (TLR3) Is Required for Ligand ...
TLR3 (Toll-like receptor 3) recognizes dsRNA, a potent indicator of viral infection. The extracellular domain of TLR3 dimerizes when it binds dsRNA, and the crystal structure of the …
TLR3: Interferon induction by double-stranded RNA
2008年4月29日 · Identification of the TLR3-TICAM-1-mediated signaling cascades different from those of RIG-I/MDA5, ligand repertoire of TLR3, and dsRNA transport system provides new …