2024年11月25日 · 腹膜内注射降植烷（2,6,10,14-四甲基十五烷，或TMPD）是一种在矿物油中高浓度存在的类异戊二烯烷烃，是诱导系统性狼疮的标准方法，该系统性狼疮具有特征性器官受累和自身抗体。 各种小鼠品系，例如BALB/c和C57BL/6。 然而，不同的菌株表现出不同的临床表现，表明环境在狼疮中具有相当大的重要性。 PIL已被证明是了解系统性自身免疫涉及的多种机制的有用工具。 此外，它可以被认为是评估SLE患者中环境贡献和干扰素特征的有效模型。 例 …

2018年10月1日 · Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice, which may provide novel ideas and theoretical support for understanding...

2022年2月23日 · 通过检测来自病毒感染小鼠或tmpd诱导sle小鼠体内的巨噬细胞，以及临床sle病人的外周血单核细胞，研究人员均发现akt2表达下降。 敲除Akt2的小鼠通过升高Ifnb1的表达，有助于抵御病毒感染，但加重SLE的发病程度。

2009年9月1日 · Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody production strictly depend on signaling through the interferon (IFN)-I receptor.

We found that both cGAS- and STING-deficiency not only failed to rescue mice from TMPD-induced SLE, but resulted in increased autoantibody production and higher proteinuria levels compared to cGAS STING sufficient mice.

In the present study, we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2, 6, 10, 14-tetramethylpentadecane (TMPD). Myeloid cell-specific FBXW7-deficient (Lysm + FBXW7 f/f ) C57BL/6 mice showed decreased immune complex accumulation, glomerulonephritis, glomerular mesangial ...

In the present study, we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2, 6, 10, 14-tetramethylpentadecane (TMPD)....

Similar to its proposed role in human SLE, signaling via the IFNAR is central to the pathogenesis of autoantibodies and glomerulonephritis in TMPD-induced lupus. This lupus model is the first animal model shown to recapitulate the "interferon signature" in peripheral blood.

系统性红斑狼疮(Systemic lupus erythematosus, SLE)是一种严重的自身免疫性疾病，其特征是免疫调节功能障碍，炎症细胞因子产生过多，自身反应性细胞和抗体 [1] 攻击正常组织(心脏、关节、皮肤、肺、血管、肝、肾和神经系统) [1] 。

2023年7月19日 · Next, we investigated how EBI2-deficient macrophages affect the development of SLE in vivo using TMPD-induced lupus model, which features the development of lipogranulomas adhering to peritoneal mesothelial cell surface and …