肿瘤基线代谢参数预测弥漫大B细胞淋巴瘤预后的价值
基线肿瘤代谢指标包括最大葡萄糖标准摄取值（SUVmax）、平均摄取值（SUVmean）、总肿瘤代谢体积（TMTV）、总糖酵解率（TLG）。 分析肿瘤代谢参数及临床和血液学相关指标对治疗的影响。 结果 51例患者中，20例复发或进展，中位无进展生存（PFS）期时间为12.0个月（1.0~64.0个月），2年PFS率为25.5%（13/51）。 TMTV、TLG与血清乳酸脱氢酶（LDH）水平的相关性较强。 单因素分析显示Ann Arbor分期、NCCN-IPI评分、TMTV均对预后有显著相关 …
Baseline total metabolic tumor volume combined with …
New volume-based parameters derived from baseline 18 F-FDG PET/CT, such as total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), can reflect metabolic volume and activity and have been proposed as quantitative indexes of tumor metabolism biomarkers in Hodgkin’s and B-cell lymphomas [8].
Combining Total Metabolic Tumor Volume With …
2024年12月16日 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.
Prognostic relevance of tumor-infiltrating CD4+ cells and total ...
2024年9月1日 · High TMTV and low TI CD4 + cells were independently associated with poor prognosis and their combination identified the most adverse population (3-year progression-free survival: 32.3%, 95% confidence interval [CI]: 19.4-53.7; …
A novel prognostic model utilizing TMTV and SUVmax from
2025年3月3日 · This study aimed to evaluate the prognostic value of 18F-FDG PET/CT parameters including maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), and to develop a new prognostic model for ENKTL. We analyzed 390 ENKTL patients with comprehensive clinical and survival data.
Metabolic tumor volume predicts overall survival and local control …
Our findings suggest that for patients with large tMTV-pre, achieving a therapeutic radiation dose may help maximize OS. Prospective studies are needed to confirm this finding. Higher tMTV-pre is associated with significantly worse OS in inoperable stage III …
Full automation of total metabolic tumor volume from FDG …
2022年8月12日 · Our findings generally agree with the literature for TMTV [12, 32]. The observation of a significant role of aTMTV in predicting survival outcomes in such a setting emphasizes the strength of aTMTV as a prognostic biomarker for identification of patients with DLBCL at high risk at the time of diagnosis, regardless of response to therapy [ 32 ].
Locally Advanced Non-Small Cell Lung Cancer - redjournal.org
2014年11月15日 · Higher pretreatment tMTV is associated with significantly worse OS in inoperable stage III NSCLC treated with definitive CRT. Our findings suggest that the negative impact of high tMTV may be overcome by dose escalation to ≥70 Gy.
High total metabolic tumor volume at baseline predicts survival ...
High baseline TMTV (±ECOG) was a strong prognosticator of inferior PFS and OS in REMARC patients post-R-CHOP, irrespective of maintenance. Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to aid stratification to innovative treatment.
TMTV-Net：淋巴瘤 PET/CT 图像中的全自动总代谢肿瘤体积分 …
总代谢肿瘤体积 （TMTV） 分割具有重要价值，可用于淋巴瘤管理的定量成像生物标志物。 在这项工作中，我们使用级联方法解决了从 PET/CT 扫描中自动描绘淋巴瘤肿瘤的具有挑战性的任务。 我们的研究包括来自四个不同中心的 1418 例 2- [18 F]FDG PET/CT 扫描。 数据集分为 900 次扫描用于开发/验证/测试阶段和 518 次用于多中心外部测试。 前者包括 450 例淋巴瘤、肺癌和黑色素瘤扫描，以及 450 例阴性扫描，而后者由来自不同中心的淋巴瘤患者组成，具有弥漫性大 B …