2025年2月22日 · Baseline- and residual-TMTV strongly influence prognosis and response in lymphoma patients. The novel personalized pTMTV liver method offers improved accuracy of patient stratification, particularly for those with DS4-5, providing more reliable risk assessment. Larger cohorts are needed to …

2024年1月1日 · An initial pooled analysis of three prospective trials 4 including patients mainly treated with the R-CHOP regimen and without maintenance identified a superior 5-year progression-free survival (PFS) of 65% (95% CI 55.3-73.3) for patients with a low TMTV versus 33% (95% CI 20.0-46.1) for those with a high TMTV, independently from the end of ...

2024年12月16日 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.

2025年2月22日 · We analyzed 91 patients with relapsed/refractory diffuse-large-B-cell lymphoma and follicular lymphoma from the GATA trial, comparing patient’s outcome according to three segmentation methods: TMTV 41%, TMTV 4, and pTMTV liver. pTMTV liver used a threshold of 200%SUVmean liver aligning with 125%SUVmax liver to enhance standardization and reduce ...

2025年3月3日 · Metabolic tumor volume (MTV) was calculated using a 41% SUVmax threshold, and TLG was computed as MTV multiplied by the average SUV. Progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan–Meier curves and compared with log-rank tests. Optimal cut-off values were determined using the Youden’ index.

Receiver-operating-characteristic curves for TMTV PARS and TMTV REF for 4-y PFS (A) and 4-y OS (B). Areas under receiver-operating-characteristic curves (AUC) and optimal TMTV cutoffs are reported.

2024年11月5日 · Despite its validation across various lymphoma subtypes, TMTV cut-offs for risk stratification vary due to differences in segmentation methods. This study aims to compare the prognostic value of three common segmentation methods: SUV4 SUV41% and SUV2.5, across different lymphoma patient populations.

2017年2月1日 · On a dedicated workstation, we measured the TMTV with 4 adaptive thresholding methods based on characteristic image parameters: Daisne (Da) modified, based on signal-to-background ratio; Nestle (Ns), based on tumor and background intensities; Fit, including a 3-dimensional geometric model based on spatial resolution (Fit); and Black (Bl), based ...

2018年4月4日 · High total metabolic tumor volume (TMTV), computed from baseline 18 F-fluorodeoxyglucose–positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTCs) and cell-free DNA (cfDNA) may also reflect tumor burden and be of prognostic value.

We analyzed 91 patients with relapsed/refractory diffuse-large-B-cell lymphoma and follicular lymphoma from the GATA trial, comparing patient’s outcome according to three segmentation methods: TMTV 41%, TMTV 4, and pTMTV liver. pTMTV liver used a threshold of 200%SUVmean liver aligning with 125%SUVmax liver to enhance standardization and ...