基线肿瘤代谢指标包括最大葡萄糖标准摄取值（SUVmax）、平均摄取值（SUVmean）、总肿瘤代谢体积（TMTV）、总糖酵解率（TLG）。 分析肿瘤代谢参数及临床和血液学相关指标对治疗的影响。 结果 51例患者中，20例复发或进展，中位无进展生存（PFS）期时间为12.0个月（1.0~64.0个月），2年PFS率为25.5%（13/51）。 TMTV、TLG与血清乳酸脱氢酶（LDH）水平的相关性较强。 单因素分析显示Ann Arbor分期、NCCN-IPI评分、TMTV均对预后有显著相关 …

2024年12月23日 · Disease burden is a critical determinant of outcomes in CAR-T therapy for B-cell lymphomas, and one of the most widely used techniques for its assessment is Total Metabolic Tumor Volume (TMTV) measured via [18 F]FDG PET/CT. Biological parameters may further refine the risk profile.

Total metabolic tumor volume (TMTV), a new parameter extracted from baseline FDG-PET/CT, has been recently proposed by several groups as a prognosticator in lymphomas before first-line treatment. TMTV, the sum of the metabolic volume of each lesion, ...

2017年2月1日 · The purpose of this study was to compare in a large series of peripheral T cell lymphoma, as a model of diffuse disease, the prognostic value of baseline total metabolic tumor volume (TMTV) measured on 18F-FDG PET/CT with adaptive thresholding methods with TMTV measured with a fixed 41% SUVmax threshold method.

We defined a TMTV greater than 48.4 cm 3 during CAR‐T manufacturing as a predictor of poor prognosis, with only a 20% probability of PFS at 6 months. These findings align with previous studies that have demonstrated a strong association between high tumor burden and inferior outcomes after CAR‐T therapy, while excellent responses have been ...

2020年4月16日 · Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to aid stratification to innovative treatment. Previous studies suggested high baseline total metabolic tumor volume (TMTV) negatively impacts survival of DLBCL patients. We analyzed the prognostic impact of …

2022年2月2日 · There was a significant difference between median TMTV in the two groups: 48 cm3 in the favorable and 87 cm3 in the unfavorable group. Using two approaches (X-tile analysis and receiver operating characteristic analysis), the …

2024年9月3日 · Total metabolic tumor volume (TMTV) is prognostic in lymphoma. However, cutoff values for risk stratification vary markedly, according to the tumor delineation method used. We aimed to create a standardized TMTV benchmark dataset allowing TMTV to be tested and applied as a reproducible biomarker.

Baseline TMTV is a strong prognostic factor of POD24 and PFS in advanced FL, even in the era of antibody maintenance. SUV max was not predictive of PFS in either treatment arm. TMTV combined with FLIPI score identified a subgroup of patients (16%) at high risk of relapse with a 6-year PFS of 41.0%.

2018年4月10日 · High total metabolic tumor volume (TMTV), computed from baseline 18 F-fluorodeoxyglucose-positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTCs) and cell-free DNA (cfDNA) may also reflect tumor burden and be of prognostic value. The aim of our study was to correlate CTCs ...