With a median follow-up of 6.5 years, the 6-year progression-free survival (PFS) was 57.8%, the median TMTV was 284 cm 3, SUV max was 11.3 and SD max was 0.32 m −1, with no significant difference between arms.

2025年3月3日 · This study aimed to evaluate the prognostic value of 18F-FDG PET/CT parameters including maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), and to develop a new prognostic model for ENKTL. We analyzed 390 ENKTL patients with comprehensive clinical and survival data.

基线肿瘤代谢指标包括最大葡萄糖标准摄取值（SUVmax）、平均摄取值（SUVmean）、总肿瘤代谢体积（TMTV）、总糖酵解率（TLG）。 分析肿瘤代谢参数及临床和血液学相关指标对治疗的影响。 结果 51例患者中，20例复发或进展，中位无进展生存（PFS）期时间为12.0个月（1.0~64.0个月），2年PFS率为25.5%（13/51）。 TMTV、TLG与血清乳酸脱氢酶（LDH）水平的相关性较强。 单因素分析显示Ann Arbor分期、NCCN-IPI评分、TMTV均对预后有显著相关 …

2021年12月1日 · Baseline TMTV appears to be a useful independent prognostic factor for predicting relapse in advanced-stage HL in ABVD subgroup, with a tendency of survival curves separation in BEACOPP subgroup.

Using the optimal threshold by ROC curve to classify patients into three TMTV 1 subgroups (0 cm 3; 0–57 cm 3; >57 cm 3), TMTV 1 prognostic stratification was independent of PERCIST criteria on both PFS and OS, and significantly outperformed them.

2024年12月16日 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.

Key points: • In a retrospective cohort of 57 metastatic melanoma patients treated with BRAF/MEK inhibitors, a TMTV > 56 cm 3 at baseline [18 F]FDG PET/CT was significantly correlated with a shorter PFS and OS. • The combined use of baseline TMTV along with PET response during treatment allowed for the identification of three groups of ...

2020年12月2日 · TMTV is a measurement of the viable fraction of all tumor sites, and is a better predictor of survival than bulky disease. Although no correlation was found between TMTV or TLG and bulky disease, this study revealed that patients with high TMTV or TLG were more likely to have more than two sites of extranodal involvement.

The total metabolic tumor volume (TMTV) was computed using the 41% SUV max method. Results: With a median follow-up of 6.5 years, the 6-year progression-free survival (PFS) was 57.8%, the median TMTV was 284 cm 3, SUV max was 11.3 and SD max was 0.32 m-1, with no significant difference between arms.

• Total metabolic tumor volume (TMTV) is a quantitative radiological assessment of total tumor burden that can be derived from 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans.1 • Although the TMTV metric has prognostic value in diffuse large B-cell lymphoma (DLBCL)2,3