This repository employs a deep-learning method for the automated segmentation of total metabolic tumor volume (TMTV) in whole-body [18]F-FDG PET/CT images, with an emphasis on multi-center generali...

Total metabolic tumor volume (TMTV), calculated from 18 F-FDG PET/CT baseline studies, is a prognostic factor in diffuse large B-cell lymphoma (DLBCL) whose measurement requires the segmentation of all malignant foci throughout the body.

Our model, TMTV-Net, is specifically designed to automate TMTV segmentation from PET/CT scans. TMTV-Net demonstrates robust performance and adaptability in TMTV segmentation across diverse multi-site external datasets, encompassing various lymphoma subtypes.

Measuring total metabolic tumor volume (TMTV) on 18 F-FDG PET/CT images in clinical practice requires a fast, reliable, and easy-to-perform multilesional segmentation workflow. We conducted a field test to derive total metabolic volumes using 5 representative baseline 18 F-FDG PET/CT scans from patients with diffuse large B-cell lymphoma. The scans were transferred to …

2024年9月3日 · Total metabolic tumor volume (TMTV) is prognostic in lymphoma. However, cutoff values for risk stratification vary markedly, according to the tumor delineation method used. We aimed to create a standardized TMTV benchmark dataset allowing TMTV to be tested and applied as a reproducible biomarker.

2024年2月8日 · Total metabolic tumor volume (TMTV) segmentation has significant value enabling quantitative imaging biomarkers for lymphoma management. In this work, we tackle the challenging task of automated tumor delineation in lymphoma from PET/CT scans using a cascaded approach. Our study included 1418 2-[18F]FDG …

5 天之前 · Measuring total metabolic tumor volume (TMTV) on 18F-FDG PET/CT images in clinical practice requires a fast, reliable, and easy-to-perform multilesional segmentation workflow. We conducted a field test to derive total metabolic volumes using 5 representative baseline 18F-FDG PET/CT scans from patients with diffuse large B-cell lymphoma. The scans were transferred to 10 different sites or ...

它首次证实了 SUVmax、TMTV 和 TLG 是 ENKTL 患者独立的预后因素，构建的新型预后模型把 18 F-FDG PET/CT 参数和临床数据结合起来，大大提高了预测患者生存期的准确性，能帮助医生更科学地制定个性化治疗方案。 不过，研究也存在一些局限性，比如不同中心测量 PET/CT 参数的技术有差异，治疗方案也不太统一，样本量可能还不够大，研究是回顾性的可能存在偏倚。 但这并不影响它为后续研究指明方向，未来还需要更多前瞻性研究来进一步验证这个模型的实用性和 …

2020年7月28日 · Total metabolic tumor volume (TMTV) is a promising quantitative biomarker for therapy assessment and prognosis in Hodgkin Lymphoma affected patients that allows...

2023年11月2日 · Background: Total metabolic tumor volume (TMTV) in 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) predicts patient outcome in follicular lymphoma (FL); however, it requires laborious segmentation of all lesions. We investigated the prognostic value of the metabolic bulk volume (MBV) obtained from the single largest lesion.