TNF （Tumor Necrosis Factor）又称TNFα，是一种能直接杀伤肿瘤细胞且对正常细胞无明显细胞毒性的细胞因子，是一种参与全身炎症的细胞信号蛋白，是构成急性期反应的细胞因子之一。 它主要由活化的巨噬细胞产生，但其他大多数免疫细胞，例如 CD4+淋巴细胞、NK 细胞、中性粒细胞、肥大细胞、嗜酸性粒细胞都可以产生，神经系统里的神经元也同样可以产生。 TNF通过两种受体TNFR1（也称为p55）和 TNFR2 （也称为p75）起作用。 TNFR1在大多数组织中表达，与 …

2015年5月26日 · TNF signalling through TNFR1 and TNFR2 leading to nuclear factor-κB (NF-κB) activation promotes cell survival. A hallmark of TNF-dependent NF-κB signalling is the complex regulation of...

2019年1月10日 · Our results demonstrate that exogenous TNFα may enhance the differentiation and function of iTreg via TNFR2 signaling. The expression of TNFR2 on Treg might be downregulated in some autoimmune...

2024年3月11日 · TNF controls inflammatory signalling and cell fate through binding to two distinct receptors: TNFR1 and TNFR2, which are differentially expressed in different cell types. TNFR1 contains a death...

2020年11月24日 · In this review, we describe the signaling complexes formed by TNFR1 and TNFR2 that lead to each potential cellular response, namely, canonical and non-canonical NF-κB activation, apoptosis and necrosis. This is followed by a discussion of data from in vivo mouse and human studies to examine the differential impacts of TNFR1 versus TNFR2 signaling.

2015年2月1日 · TNF exerts its biological responses via interaction with two cell surface receptors: TNFR1 and TNFR2. (TNFRs). These receptors trigger shared and distinct signaling pathways upon TNF binding, which in turn result in cellular outputs that may promote tissue injury on one hand but may also induce protective, beneficial responses.

2019年7月30日 · These findings suggest how membrane organization alters TNFR1 signaling, insights that may direct the development of TNF-targeted therapeutics with increased potency. Signaling by the ubiquitously expressed tumor necrosis factor receptor 1 (TNFR1) after ligand binding plays an essential role in determining whether cells exhibit survival or death.

Tumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF is assembled to a homotrimer and binds to its receptors (TNFR1, TNFR2) resulting in the trimerization of TNFR1 or TNFR2.

2008年6月11日 · Ligand-activated tumour-necrosis factor receptor-1 (TNFR1) promotes the activation of the transcription factor nuclear factor-κB (NF-κB) via recruitment of...

2025年1月15日 · Given the potential risks associated with targeting tumor necrosis factor-alpha (TNF-α), selective inhibition of the TNFR1 signaling pathway has been proposed as a promising strategy to reduce side effects and enhance therapeutic efficacy.