2024年12月25日 · TNFRSF4 (TNF Receptor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include Immunodeficiency 16 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28.

OX40 (CD134, TNFRSF4) 最初被定义为T细胞活化标记物，后发现是具有共激活功能的 NGFR/TNFR超家族 成员。 OX40基因位于人1号染色体（小鼠4号染色体），编码一种50kD的一型跨膜糖蛋白。 胞外区有191个氨基酸，包含了三个完整的以及一个稍短的富含半胱氨酸结构域（CRDs）。 主要在活化的效应T细胞（Teffs）和调节性T细胞（Tregs）上表达，也在 NKT细胞， NK细胞 和 嗜中性粒细胞 上表达。 OX40与配体OX40L（CD252, TNFSF4）结合传递共刺激 …

2021年12月8日 · BM Tregs in CML were characterized by the selective expression of tumor necrosis factor receptor 4 (Tnfrsf4). Stimulation of Tnfrsf4 signaling did not deplete Tregs but reduced the capacity of Tregs to protect LSCs from CD8+ CTL-mediated killing.

小鼠基因敲除研究表明，该受体促进细胞凋亡抑制剂 BCL2 和 BCL2lL1/BCL2-XL 的表达，从而抑制细胞凋亡。 敲除研究还表明该受体在 CD4+ T 细胞反应以及 T 细胞依赖性 B 细胞增殖和分化中的作用。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-gamma Signature, Signatures of Immune Infiltrates, and Survival.

2025年2月8日 · Enables tumor necrosis factor receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; inflammatory response; and regulation of macromolecule metabolic process.

tnfrsf4，即肿瘤坏死因子受体超家族成员4，也被称作cd137或ox40。 它是一种主要在活化的T细胞表面表达的共刺激分子。 TNFRSF4的作用机制涉及与其配体TNFSF4（也称为OX40L）的结合，这种结合增强了T细胞的存活、增殖和分化，对维持T细胞介导的免疫应答至关重要。

2024年6月15日 · TNFRSF4 plays a significant role in cancer progression, especially in hepatocellular carcinoma (HCC). This study aims to investigate the prognostic value of TNFRSF4 expression in patients with HCC and to develop a predictive pathomics model for its expression.

2025年2月8日 · Clinical resource with information about TNFRSF4, Combined immunodeficiency due to OX40 deficiency, Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease., and available tests.