Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.

2024年12月25日 · TNFSF11 (TNF Superfamily Member 11) is a Protein Coding gene. Diseases associated with TNFSF11 include Osteopetrosis, Autosomal Recessive 2 and Autosomal Recessive Malignant Osteopetrosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TNF Superfamily - Human Ligand-Receptor …

Gene ID: 8600, updated on 8-Feb-2025. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.

肿瘤坏死因子相关激活诱导因子(trance)，又名肿瘤坏死因子配体超家族成员11(tnfsf11)、核因子κb受体活化因子配基(rankl)，是tnf超家族成员。 成骨细胞、CD4+和CD8+T细胞、巨核细胞、支气管和肠道上皮细胞等都可表达TRANCE。

该基因编码肿瘤坏死因子 (TNF) 细胞因子家族的成员，该家族是骨保护素的配体，是破骨细胞分化和激活的关键因子。 该蛋白被证明是一种树突状细胞存活因子，并参与 T 细胞依赖性免疫反应的调节。 据报道，T 细胞活化可诱导该基因的表达，并导致破骨细胞生成和骨质流失增加。 该蛋白显示通过涉及 Src 激酶和肿瘤坏死因子受体相关因子 (TRAF) 6 的信号复合物激活抗凋亡激酶 Akt /PKB，这表明该蛋白可能在细胞凋亡的调节中起作用。 小鼠相关基因的靶向破坏导致严重的 …

2025年2月8日 · mouse Tnfsf11 gene locus contains the necessary genetic information to direct appropriate tissue-specific and factor-regulated RANKL expression in vivo. These findings suggest that RACK1 specifies the RANKL-stimulated activation of p38 MAPK by facilitating the association of MKK6 with TAK1

2025年1月4日 · Title: Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma. Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers.

2024年4月9日 · Our research has provided valuable insights into the role of TNFSF11, revealing its negative regulation of GPX4, which could be influential in crafting therapeutic strategies. These findings set the stage for further exploration into the mechanisms underpinning the relationship between TNFSF11 and G …

用于研究常染色体隐性骨硬化病 2 和骨质疏松症。 该基因的人类直系同源物与常染色体隐性骨硬化病 2 和骨质疏松症有关。 与人类 TNFSF11（TNF 超家族成员 11）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity.

Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differenti...