The TNNT1 gene is located at 19q13.4 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin T (ssTnT). ssTnT is an ~32-kDa protein consisting of 262 amino acids (including the first methionine) with an isoelectric point (pI) of 5.95.

2024年12月25日 · TNNT1 (Troponin T1, Slow Skeletal Type) is a Protein Coding gene. Diseases associated with TNNT1 include Nemaline Myopathy 5A, Autosomal Recessive, Severe Infantile and Nemaline Myopathy 5B, Autosomal Recessive, Childhood-Onset. Among its related pathways are Striated muscle contraction pathway and Cardiac conduction.

Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy. TNNT1, negatively regulated by miR-873, promotes the progression of colorectal cancer.

2016年5月10日 · Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.

Troponin T1 (TNNT1) is a subunit of troponin that has been linked to neuromuscular disorder. Recently, it was reported that TNNT1 facilitates the proliferation of breast cancer cells. Interestingly, Cancer Genome Atlas data indicate that its overexpression is associated with an unfavorable prognosis of colorectal cancer (CRC) patients.

2016年5月10日 · Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.

Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.

该基因的突变会导致 5 型线形肌病，也称为阿米什线形肌病，这是一种神经肌肉疾病，其特征是肌肉无力和骨骼肌纤维中的杆状或线形夹杂物，影响婴儿，导致因呼吸功能不全而死亡，通常在第二年。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere.

2024年10月10日 · Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy. TNNT1, a prognostic indicator in colon adenocarcinoma, regulates cell behaviors and mediates EMT process. TNNT1 facilitates proliferation of breast cancer cells by promoting G (1)/S phase transition.

2025年2月8日 · Data show that cardiac expression of slow skeletal troponin T (Tnnt1) strictly depends on the physical interaction between GATA4-FOG2 in the myocardium of both atria and ventricles. This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction.