Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene. [5] [6]

Dec 25, 2024 · TNP1 (Transition Protein 1) is a Protein Coding gene. Diseases associated with TNP1 include Azoospermia and Male Infertility. Among its related pathways is Transcription_CREM signaling in testis. Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals.

TNP1, or TP1, localized in nucleus, is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines. Recently, TNP-1 was used as a germ cell marker in condensing spermatids.

Transition protein-1 是单倍体基因组的精子细胞特异性产物，它取代组蛋白并在成熟精子中被鱼精蛋白取代 (参见 PRM1、MIM 182880；PRM2、MIM 182890) (Luerssen 等人，1990 [PubMed 2249851) ]) . [OMIM 提供，2008 年 3 月]

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]). [supplied by OMIM, Mar 2008]

Title: The TNP1 haplotype - GCG is associated with azoospermia. The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.

通过单细胞转录组分析，研究团队发现人类精子细胞可分为四种类型（s1~s4）。进一步通过ddx4、tnp1、prm1、pna等标志分子的蛋白表达特征，证实人类睾丸中存在上述四种精子细胞类型（图4b，4c）。

Bovine nucleoprotein transitions (TNPs), specifically TNP1 and TNP2, are essential molecules in sperm nucleus rich in arginine and lysine. These molecules act in the phase between histone expulsion and before incorporation of protamine in the spermatid nucleus.

Mar 27, 2024 · Nuclear transition protein TNP1 is a crucial player mediating histone-protamine exchange in condensing spermatids. A unique combination of intrinsic disorder and multivalent properties turns TNP1 into an ideal agent for orchestrating the …

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]). [supplied by OMIM, Mar 2008]