Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.

2024年4月5日 · Topotecan is used to treat ovarian cancer, small cell lung cancer, and certain types of cervical cancer. Topotecan is usually given after other treatments have failed. Topotecan may also be used for purposes not listed in this medication guide.

Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after other treatments have failed. This medicine is also used to treat a certain type of lung cancer called small cell lung cancer.

Topotecan hydrochloride is a chemotherapy drug that damages the DNA of cancer cells and other rapidly growing cells, causing them to die. FDA label information for this drug is available at DailyMed. Topotecan hydrochloride is approved to be used alone or with other drugs to treat:

2019年8月3日 · Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity.

托普樂肯 （Topotecan；商品名： Hycamtin ®， 癌康定）是一種化學治療藥物，為拓樸異構酶I抑制物，一般用來治療 卵巢癌 與 肺癌 等癌症。 为 静脉注射，不过有口服的研究。

Topotecan, a water-soluble analogue of camptothecin, is a newly available cytotoxic agent which acts as an inhibitor of topoisomerase I, an enzyme necessary for DNA replication. Topotecan is a semisynthetic product derived from camptothecin, which was discovered during a …

拓扑替康（Topotecan）为喜树碱半合成衍生物，是一种抑制拓扑异构酶Ⅰ的药物，能与拓扑异构酶Ⅰ-DNA复合物结合，从而阻碍断裂DNA单链的重新链接。 形成的拓扑替康-拓扑异构酶Ⅰ-DNA三元复合物与复制酶相互作用，造成双链DNA的损伤。

Topotecan is used to treat small cell lung cancer (a type of cancer that begins in the lungs) that was successfully treated with a different chemotherapy medication but has returned no sooner than 45 days after the last dose of the first chemotherapy medication was taken.

拓扑替康 (Topotecan) 所有名称: 拓扑替康 欣泽 HCI Topotecan. 适应症: 对于一线化疗失败的，采用盐酸拓扑替康+顺铂二线治疗，但不能耐受静脉给药的广泛期小细胞肺癌患者，可试用本品与顺铂联合治疗。