The target of rapamycin (TOR) kinase functions in two multiprotein complexes, TORC1 and TORC2. Although both complexes are evolutionarily conserved, only TORC1 is acutely inhibited by rapamycin. Consequently, only TORC1 signaling is relatively well understood; and, at present, only mammalian TORC1 i …

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP. [8] CRTC2 is thought to drive tumorigenesis in STK11 (LKB1)-null non-small cell lung cancers (NSCLC). [9]

2016年6月1日 · Recent electron microscopy structures provide a framework for understanding how TORC2 is regulated as well as the specific functions of individual subunits.

2016年5月6日 · Here we review these recent advances as well as observations made from tissue-specific mTORC2 knockout mice. Together these studies help define TORC2 structure–function relationships and suggest that mammalian TORC2 may …

We find that plasma membrane localization of TORC2 is essential for viability and mediated by lipid binding of the C-terminal domain of the Avo1 subunit. From these data, we suggest that the TOR complexes are spatially separated to determine downstream signaling specificity and their responsiveness to different inputs.

2014年7月3日 · In budding yeast, TORC2 controls lipid biosynthesis and actin cytoskeleton through downstream AGC kinases, which are now, surprisingly, implicated in the survival of oxidative DNA damage. Preliminary data from mTORC2 modulation in cancer cells suggest that an extension to human chemotherapy is worth exploring.

2021年7月29日 · As a TOR complex, TORC2 lies at the nexus of many signaling pathways and directs a diverse array of fundamental processes such as cell survival, proliferation, and metabolism by integrating environmental and intracellular cues. The dysregulation of TORC2 activity disrupts cellular homeostasis and leads to many pathophysiological conditions.

2018年8月27日 · Active TORC2 promotes cell growth by activating downstream AGC-family kinases, such as YPK1 or 2 in yeast and Akt in mammalian cells, to regulate cell signalling cascades and trigger ...

2011年3月4日 · The target of rapamycin complex 2 (TORC2) is a key regulator of cell growth. Zinzalla et al. (2011) now provide evidence that TORC2 is activated by direct association with the ribosome, which may ensure that TORC2 activity is calibrated to …

多年来，抑制中枢生长调节激酶 TOR 参与两种复合物TORC1 和TORC2 一直是代谢和癌症研究的焦点。 大多数研究都涉及 TORC1（雷帕霉素的典型靶标）以及该复合物在自噬、蛋白质合成和细胞生长控制中的作用。