TOX transcriptionally and epigenetically programs CD8 - Nature
2019年6月17日 · Exhausted CD8 + T (T ex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional …
TOX is expressed by exhausted and polyfunctional human effector memory CD8
Our collective dataset provides an expression atlas for TOX and TCF-1 in the human CD8 + T cell landscape under physiological conditions and under challenge from a relentless pathogen. We …
专家点评 | 3篇Nature1篇Nat Immuno揭示调控耗竭CD8+T细胞的 …
本文发现，tox在功能障碍的肿瘤特异性cd8+t细胞中高表达，且tox的表达需要慢性的tcr刺激和nfat的激活。在体外效应t细胞中过表达tox可在转录水平上诱导出耗竭相关变化。相反，tst …
3篇Nature，揭示TOX蛋白在调节免疫T细胞功能的关键作用_光谱网
5 天之前 · John Wherry团队在Nature 在线发表题为“TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion”的研究论文，研究人员将HMG-box转录因子TOX鉴定为TEX …
Continuous expression of TOX safeguards exhausted CD8 T cell
2025年3月7日 · We used genetic and shRNA approaches to inducibly ablate functional TOX expression in CD8 T ex cells in vivo using the mouse model of LCMV infection and …
TOX transcriptionally and epigenetically programs CD8+ T cell ...
Exhausted CD8 + T (T ex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared …
TOX is a critical regulator of tumour-specific T cell ... - Nature
2019年6月17日 · We show that TOX is highly expressed in dysfunctional TST cells from tumours and in exhausted T cells during chronic viral infection. Expression of TOX is driven by chronic …
单细胞转录组和表观组学图谱揭示效应、记忆和耗竭CD8 T细胞在 …
2022年3月27日 · 在本文中，我们基于淋巴细胞脉络丛脑膜炎病毒（LCMV）的急性和慢性感染模型，使用单细胞scRNA-seq和scATAC-seq数据的整合分析来解决这些问题。 我们的分析结果 …
Differentiation of Cytotoxic CD8 - Wiley Online Library
4 天之前 · Since TOX is known to be critical for the maintenance of TCF1 + stem-like CD8 + T cells, reduced expression of TOX may render stem-like CD8 + T cells more susceptible to …
CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8
2024年9月23日 · CXCR4 is highly expressed in CD8 + PD-1high exhausted T cells within tumors. Blocking CXCR4 enhances immunotherapy by reducing exhausted CD8 + T cell phenotype. …