2024年12月25日 · TP53BP2 (Tumor Protein P53 Binding Protein 2) is a Protein Coding gene. Diseases associated with TP53BP2 include Chromosome 1Q41-Q42 Deletion Syndrome and Lung Cancer. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling.

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. [5] [6] [7] Multiple transcript variants encoding different isoforms have been found for …

2023年9月1日 · During tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating protein 2 of p53 (ASPP2), plays a critical role in p53 dependent and independent manner. Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients.

2024年4月2日 · 首都医科大学附属北京佑安医院的Xiaoni Liu/Ying Shi教授团队在本刊发表了题为“TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities”的综述文章，总结了TP53BP2的抑癌功能及其在治疗癌症方面的潜力。

该基因编码 p53 相互作用蛋白的 ASPP (p53 凋亡刺激蛋白) 家族的成员。 该蛋白质包含四个锚蛋白重复序列和一个参与蛋白质-蛋白质相互作用的 SH3 结构域。 它位于细胞质的核周区域，通过与其他调节分子 (包括 p53 家族成员) 的相互作用调节细胞凋亡和细胞生长。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins.

ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma. identified a previously unreported Merlin-binding protein, apoptosis-stimulated p53 protein 2 (ASPP2, also called Tp53bp2), that bound to closed-conformation Merlin predominately through the FERM domain.

In vitro and in vivo experiments demonstrated that loss of TP53BP2 decreased interferon-stimulated gene levels and the anti-HBV effect of IFN-α. Mechanistically, TP53BP2 was found to downregulate SOCS2, thereby facilitating JAK/STAT signaling.

2025年1月4日 · Title: Higher TP53BP2 expression is associated with HBsAg loss in peginterferon-α-treated patients with chronic hepatitis B. ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection.

2024年1月26日 · This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions.

TP53BP2的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码的ASPP（细胞凋亡刺激的p53蛋白）家族的p53相互作用蛋白成员。 该蛋白包含四个锚蛋白重复序列??和参与蛋白质 - 蛋白质相互作用的SH3结构域。 它被定位于细胞质的核周区，并通过与其他调节分子包括p53家族的成员相互作用调节细胞凋亡和细胞生长。 已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2008年7月提供]