The term transcriptome is a portmanteau of the words transcript and genome; it is associated with the process of transcript production during the biological process of transcription. The early stages of transcriptome annotations began with cDNA libraries published in the 1980s.

An anatomically comprehensive atlas of the adult human transcriptome . Brain-wide variation in gene expression strongly reflects the distributions of major cell classes such as neurons, oligodendrocytes, astrocytes, and microglia.

2011年2月18日 · TRAM (Transcriptome Mapper) is a new general tool that allows the simple generation and analysis of quantitative transcriptome maps, starting from any source listing gene expression values for a given gene set (e.g. expression …

2021年7月28日 · Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in the human body. Here, we combined single-cell transcriptomics analysis with spatial antibody-based protein profiling to create a high-resolution single–cell type map of human tissues.

2025年1月27日 · Here we present spatial-Mux-seq, a multimodal spatial technology that allows simultaneous profiling of five different modalities: two histone modifications, chromatin accessibility, whole...

2023年12月21日 · Spatial transcriptomics presents the opportunity to map this expression to specific locations on the tissue, which may also be associated with the presence of specific processes or cells. Generating activity maps of gene expression can reveal process-level insights into the functioning of these genes.

2023年12月21日 · RNA sequencing in situ allows for whole-transcriptome characterization at high resolution, while retaining spatial information. This perspective discusses the challenges associated with spatial analysis and proposes how we can take advantage of practice from the geographical sciences to realize the full potential of spatial information in ...

2016年8月6日 · To construct a comprehensive human transcriptome map, large-scale transcriptome data were collected from the ENCODE Project, the Human BodyMap 2.0 Project, and NCBI GEO human cell lines; these data included 65 unstranded and 104 stranded RNA-seq data, TSS profiles across 17 human tissues, and CPS profiles from four human cell lines (Nam et …

2025年2月22日 · A thorough theoretical treatment of FP diffusion maps, with illustrations and applications to single cell transcriptome data can be found in ref. 13. This approach allows us to reclassify ...

2011年2月1日 · TRAM (Transcriptome Mapper) is a new general tool that allows the simple generation and analysis of quantitative transcriptome maps, starting from any source listing gene expression...