2023年4月1日 · Recent findings: Regulatory T cells regulate the innate and adaptive immune responses at steady state to enforce immune tolerance in lung tissues at steady state and their control of the allergic inflammatory responses induced by allergens. This regulatory function can break down in the context of chronic asthmatic airway inflammation such that ...

Regulatory T-cells play a pivotal role in the pathogenesis of Asthma. Treg cells maintain tolerance in the lung and supress untoward immune stimulation ( 39 ). Alveolar macrophages (AMs) and plasmacytoid dendritic cells (pDCs) are the main cells promoting Foxp3 + Treg cells in the lung ( …

2020年12月2日 · Tregs modulate Th2-mediated lung inflammation, and their therapeutic potential is best described by evidence that therapies with Treg in allergic and asthma disease are associated with the induction or restoration of Treg function, e.g. glucocorticoids, allergen immunotherapy .

Asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens.

2010年2月17日 · That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated in Treg-mediated suppression of...

Regulatory T cells are a specific CD4 + T cell population involved in peripheral tolerance by inhibiting autoreactive CD4 + T cells that have eluded negative selection in the thymus and controlling inflammation in diverse biological processes, such as infection, metabolic disease, tissue repair, cancer, and hypersensitivity reactions (1, 227).

2009年9月9日 · Regulatory T cells (Treg cells) are essential in the maintenance of immunological tolerance to “self” and in the regulation of the immune response to infectious organisms, both pathogens and commensals. Furthermore, Treg cells represent a major pathway proposed to contribute to the maintenance of immune homeostasis in the airways.

Regulatory T cells (Treg) are T cells that suppress potentially harmful immune responses. In animal models of asthma, Treg has been shown to suppress inflammatory responses and airway hyper-responsiveness to maintain peripheral immune tolerance [3-5].

2020年2月17日 · Here we found that transient plasmacytoid dendritic cell (pDC) depletion during viral infection in early-life, which causes the expansion of aberrant Tregs, predisposes to allergen-induced or...

Together with studies of patients and in vitro studies of human T cells, these investigations are defining potential interventions to enhance Treg function in the airway in asthma. Existing therapies including corticosteroids and allergen immunotherapy act on Tregs, in part to increase IL-10 production, while vitamin D3 and long-acting beta ...