重新审视CD8+ Tregs：具有不同表型和特性的异质群体
2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就 …
CD8 + Regulatory T Cell – A Mystery to Be Revealed - Frontiers
2021年8月17日 · Various CD8 + T cell subsets carrying certain regulatory properties have been discovered in different experimental systems and have been named “CD8 + Tregs” (Table 1). …
Nature Immunology｜CD4+和CD8+Treg细胞在控制自身反应性免 …
2025年2月17日 · CRISPR-Cas9基因编辑 研究者利用Cas9核蛋白（RNP）电穿孔技术，在人类扁桃体T细胞中敲除FOXP3或GZMB基因，以研究CD4+ Treg和CD8+ Treg的功能缺失对免疫反 …
CD8+ Tregs revisited: A heterogeneous population with different ...
We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this …
Future prospects for CD8+ regulatory T cells in immune tolerance
In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss …
Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for ...
The primary function of Treg is to maintain immune homeostasis and self-tolerance by modulating the activity of effector lymphocyte populations. Traditionally, both CD4 + and CD8 + Treg have …
Interruption of the intratumor CD8+ T cell:Treg crosstalk improves …
2024年6月10日 · CD8 + T cells produce IL-2 and colocalize with Tregs in mouse and human melanomas. IL-2 upregulates the anti-apoptotic protein ICOS on tumor-Tregs, promoting their …
Single-cell transcriptomic analysis reveals CD8 + T cell …
2025年3月18日 · We aim to characterize the heterogeneity, developmental trajectory, regulatory network, and intercellular communication of CD8 + T cells in cervical squamous cell carcinoma …
昨天Nature、今天Cell，迟洪波团队揭示Treg细胞保护癌症新机制及CD8…
2021年2月27日 · 研究团队设计了一个基于 CRISPR/Cas9 的体内筛选系统 ， 揭示了调节CD8+T细胞命运决定的关键细胞代谢通路 。 越来越多的证据表明，CD8+T细胞的分化状态与 …
Immune regulation by CD8 + Treg cells: novel possibilities for
2018年3月5日 · Treg cells secrete several immune-modulatory cytokines (TGF-β, IL-10, TNF-α and IL-2). Tumor-induced-CD8 + Treg cells could also directly modulate activation and …
- 某些结果已被删除