2019年1月31日 · Regulatory T (T reg) cells are a subset of CD4 + T cells with immunosuppressive effects through various cellular and humoral mechanisms: cytotoxic T lymphocyte antigen 4...

Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self‐ and nonself‐antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity.

2021年8月20日 · To improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy, we review the specialized role of Tregs in clinically common and challenging organ...

2024年2月29日 · Regulatory T (T reg) cells are an immunosuppressive subset of CD4 + T cells and have important activities that restrain antitumour immune responses, making them a potential therapeutic...

Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self- and nonself-antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity.

2020年7月17日 · Regulatory T cells (Tregs) characterized by the expression of the master transcription factor forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective immunosurveillance of tumours and hampering effective antitumour immune responses in tumour-bearing hosts, constitute a current research hotspot in the field.

The role regulatory T cells (Treg) play in cancer development and progression is not clear. Earlier evidence suggested that CD4 + FOXP3 + CD25 high Treg accumulate in tumors and the peripheral blood of patients with cancer and through suppression of anti-tumor immune responses promote tumor growth.

2023年12月1日 · Unlike in the past, Treg cells have also been found to play a powerful role in cancer treatment. Treg cells exert immunosuppressive effects through various ways, such as cell-cell contact, secretion of cytokines, regulation of DC function, binding to chemokine CCL22/CCL17, and so on, and acting in the tumor microenvironment.

Foxp3-expressing regulatory T (Treg) cells, which are indispensable for preventing autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into tumor tissues, which is often associated with poor prognosis in cancer patients. Removal of Treg cells enhances anti-tumor immune responses but may also elicit autoimmunity.

2023年7月11日 · Mechanisms of Th1-like Treg suppression are unknown in cancer. Two studies in Immunity by Ayala et al. and Zagorulya et al. demonstrate that Th1-like Treg cells interact with type 1 dendritic cells in tumors and draining lymph nodes to …