2016年4月14日 · IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity. These effects are associated...

进一步通过流式和染色质免疫共沉淀（ChIP）实验，研究团队证明，抑制GSK3可以促进Treg细胞内IL-10基因启动子区转录激活相关的组蛋白修饰的富集，下调与转录抑制相关的组蛋白修饰在IL-10基因启动子区的富集。

作为肿瘤研究的热议靶点之一的Treg细胞，在肿瘤免疫过程中，Treg细胞通过表达抑制因子（CTLA4、分泌IL-10和TGF-β）来抑制过度的免疫反应，也可能促进肿瘤细胞免疫逃逸。

Here, we showed that anti-inflammatory interleukin-10 (IL-10), and not pro-inflammatory IL-6 and IL-23 cytokine signaling, endowed Treg cells with the ability to suppress pathogenic Th17 cell responses.

2015年10月15日 · In this article, we show that the presence of IL-10, in addition to TGF-β, leads to increased expansion of Foxp3(+) iTregs with enhanced CTLA-4 expression and suppressive capability, comparable to that of natural Tregs. This process is dependent on IL-10R-mediated STAT3 signaling, as supported by the lack of an IL-10 effect in patients with IL ...

2007年8月12日 · CD4 + regulatory T cells (T reg cells) that produce interleukin 10 (IL-10) are important contributors to immune homeostasis. We generated mice with a 'dual-reporter' system of the genes...

2015年10月15日 · Although it is well known that IL-10 is an important mediator of Treg suppression, the action of IL-10 on Tregs themselves is less well characterized. In this article, we show that the presence of IL-10, in addition to TGF-β, leads to increased expansion of Foxp3 + iTregs with enhanced CTLA-4 expression and suppressive capability, comparable ...

2019年4月22日 · Expression of the immunosuppressive cytokines IL-10 and IL-35 by tumor-infiltrating regulatory T cells drives exhaustion of intratumoral CD8 + T cells through a common pathway dependent on...

We hypothesize a feed-forward loop, in which IL-10Ra signaling reinforces IL-10 secretion by Tregs which potently controls Th17 development via direct and indirect mechanisms. IL-10R thus may be a promising therapeutic target for the treatment of GN.

2008年4月11日 · To directly investigate a role for IL-10 in Treg cell-mediated suppression, we generated Foxp3 YFP-Cre mice, capable of Treg cell-specific inactivation of genes of interest, and crossed them with Il10 flox/flox mice harboring a conditional Il10 allele. We found that the selective disruption of IL-10 expression in Treg cells led to spontaneous ...