2021年10月21日 · Importantly, we found that Noc4l can interact with TLR4 to inhibit its endocytosis and block the TRIF pathway, thereafter ameliorated LSI and IR in mice. Obesity …

2019年9月11日 · TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- …

2023年10月23日 · 作者接下来确定了usp19去除的trif泛素链的类型。通过将trif与仅包含单个赖氨酸残基(ko)的泛素突变体共转染，作者发现usp19从trif中去除了k27连接的多聚泛素部分。通过 …

Here, we found that TRIF is involved in mediating TLR5-induced nuclear factor κB (NFκB) and mitogen-activated protein kinases (MAPKs), specifically JNK1/2 and ERK1/2, activation in …

2017年5月1日 · sting-ko 和 trif-ko 小鼠均免受严重败血症的影响，与 wt 小鼠相比，死亡率、疾病评分、体温过低和炎性细胞因子均有所降低。sting/trif-dko 小鼠表现出与每个单一 ko 品系相 …

2013年10月25日 · TRIF-dependent signaling via TLR3 and TLR4 initiate a TRIF-RIP3 complex that directly triggers RIP3 kinase-dependent necrosis. The TRIF-RIP3 pathway is distinct from …

In this study, we confirm that TLR3, TLR4 and TRIF (TIR-domain-containing adapter-inducing interferon-β) can also have augmentative or inhibitory roles during Ad-induced immune …

2015年6月24日 · Here we show that TLR3 binding to dsRNA promotes post-translational inflammasome activation through intermediate and late TRIF/RIPK1/FADD-dependent …

2011年7月8日 · Specifically, TRIF-KO mice showed dramatically impaired lung clearance of Pseudomonas aeruginosa infections; a response that is correlated with blunted cytokine …

2020年2月21日 · Within Toll-like receptor 4 (TLR4) signaling pathway, we demonstrated that MyD88 together with TRIF generates a C1-FFL to control TBK1 phosphorylation and reduce …