Trilostane has an extensive dose range, and the starting doses can vary significantly. The manufacturer’s (Dechra) recommendation is a starting dose of 2.2 to 6.7 mg/kg once daily. Recent studies have shown, however, that lower initial doses are equally effective and may be safer.

Based on the dosage recommendation of 1-3 mg/lb (2.2-6.7 mg/kg) for treating hyperadrenocorticism in dogs, here’s the Vetoryl dosage chart. The starting dose is calculated using the dog’s weight in pounds and kilograms, providing both the minimum (1 mg/lb or 2.2 mg/kg) and maximum (3 mg/lb or 6.7 mg/kg) dosage per day.

2024年6月13日 · Your dog’s trilostane dosage will depend on their weight. The starting dose is 2.2 mg to 6.7 mg per kilogram of body weight. This is given once daily with food so that it’s absorbed better. Trilostane is available in capsules that come in five different doses: 5 mg. 10 mg. 30 mg. 60 mg. 120 mg

If clin nical status is unchanged a and pre-trilostane cortisol remains >5 ug/dL(>138 nmol/L), cons sider dividing dose to twice daily or increasing dose by 10%. 1. If the dog has co-morbidity such as dia abetes mellitus or calcinosis cutis, consider a starting dose of 1 mg/kg q12h.

The manufacturer recommends starting trilostane therapy at a dose of 2.2–6.7 mg/kg (1–3 mg/lb) once daily with food (Vetoryl® package insert). The most common starting dose in our hospital is 1–2 mg/kg (0.5–1 mg/lb) every 12 hours with food.

For detailed information on monitoring dogs treated with VETORYL Capsules and guidance on dose changes, please refer to the monitoring and treatment flowchart and the full prescribing information.

The starting dose for the treatment of hyperadrenocorticism in dogs is 1-3 mg/lb (2.2-6.7 mg/kg) once a day. Start with the lowest possible dose based on body weight and available combinations of capsule sizes.

consider a dose increase at this stage. Use combinations of capsule sizes to slowly increase the once daily dose.

The starting dose for the treatment of hyperadrenocorticism in dogs is 1-3 mg/lb (2.2-6.7 mg/kg) once a day. Start with the lowest possible dose based on body weight and available combinations of capsule sizes.

The FDA label for trilostane describes a starting dose range of 2.2 to 6.7 mg/kg q24h and recommends starting with the lowest possible dose based on body weight and available combination of capsule sizes.1 Based on the literature and extensive clinical experience, the author instead uses a lower-dosage, twice-daily dosing strategy of 0.8 to 1 mg...

Trilostane has an extensive dose range, and the starting doses can vary significantly. The manufacturer’s (Dechra) recommendation is a starting dose of 2.2 to 6.7 mg/kg once daily. Recent studies have shown, however, that lower initial doses are equally effective and may be safer.

2024年7月23日 · The initial dose of trilostane for dogs for the treatment of Cushing's disease is 2 mg/kg of body weight. The dose can be administered every 24 hours. For the best response, it is recommended to divide the dose into two doses per day. From this initial dose, the animal's response should be monitored and the dose adjusted accordingly:

Dose of Trilostane in Dogs and Cats. Dogs: Hyperadrenocorticism: 2 mg/kg p.o. q24h or 1 mg/kg p.o. q12h. Cats: Hyperadrenocorticism: 10–30 mg/cat p.o. q12–24h.

• The trilostane dose should be increased by 5 – 10 mg/dose depending on the cortisol concentrations, severity of clinical signs, size of the dog, current dose, and frequency of administration.

The starting dose for the treatment of hyperadrenocorticism in dogs is 1-3 mg/lb (2.2-6.7 mg/kg) once a day. Start with the lowest possible dose based on body weight and available combinations of capsule sizes. VETORYL Capsules should be administered with food. 2. Action at 10-14 day evaluation (Table 1)

oral dosing with trilostane can be initiated. The FDA label for trilostane describes a starting dose range of 2.2 to 6.7 mg/kg q24h and recommends starting with the lowest possible dose based on body weight and available combination of capsule sizes.1 Based on the literature and extensive clinical experience, the author instead uses a lower-dosa...

VETORYL Capsules are indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs. As with all drugs, side effects may occur.

Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of cortisol and all other steroids. Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, …

2012年12月10日 · My recommended starting dose is either 2 mg/kg given once daily or 1 mg/kg given twice daily. This is similar to the doses used in this study by Feldman (13), where the mean trilostane dose administered to his dogs was 0.86 mg/kg, twice daily (or a …

2025年3月2日 · After approximately 10-14 days at this dose, re-examine the dog and conduct a 4-6 hour post-dosing ACTH stimulation test and serum biochemistry including electrolytes. ... When switching dogs to trilostane from mitotane, mitotane (o,p’-DDD) treatment will reduce adrenal function. When mitotane therapy is stopped, it is important to wait for ...