Antibody-drug conjugates targeting TROP-2: Clinical …
Trophoblast cell surface antigen 2 (TROP-2) is a transmembrane glycoprotein involved in calcium signal transduction and is expressed in multiple tumor types. TROP-2 expression is higher in …
Trop-2 protein as a therapeutic target: A focused review on Trop-2 ...
Perrone E, Lopez S, Zeybek B, Bellone S, Bonazzoli E, Pelligra S, et al. Preclinical activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen …
A new TROP2-targeting antibody-drug conjugate shows potent …
2024年4月23日 · Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 …
Antibody-drug conjugates targeting TROP-2: Clinical …
Trophoblast cell surface antigen 2 (TROP-2) is a transmembrane glycoprotein involved in calcium signal transduction and is expressed in multiple tumor types. TROP-2 expression is higher in …
Overview of Trop-2 in Cancer: From Pre-Clinical Studies to Future ...
Trophoblast cell surface antigen-2 (Trop-2) is a widely expressed glycoprotein on a variety of different tumours. Trop-2 is considered as a marker of germ cells and is associated with …
Targeting Trop-2 in cancer: Recent research progress and clinical ...
2023年7月1日 · Trophoblast surface antigen 2 (Trop-2) is a type I transmembrane glycoprotein involved in Ca 2+ signaling in tumor cells. It is highly expressed in various tumor tissues than …
Phase 1/2 study of the trophoblast cell surface antigen 2 (TROP2 ...
2025年1月27日 · Phase 1/2 study of the trophoblast cell surface antigen 2 (TROP2) antibody-drug conjugate (ADC) sacituzumab tirumotecan (sac-TMT) as monotherapy or combination therapy …
Advances in Trop-2 targeted antibody-drug conjugates for
2024年11月1日 · This review focuses on recent advancements in Trop-2-targeted antibody-drug conjugates (ADCs) for breast cancer treatment. We comprehensively analyzed the structure …
Trop-2 protein as a therapeutic target: A focused review on Trop-2 ...
2022年2月1日 · Sacituzumab govitecan, a conjugate of anti-Trop-2 antibody and SN-38 payload (an active metabolite of irinotecan), is the first in the class that has been clinically validated …
TROP-2 directed antibody-drug conjugates (ADCs): The …
2023年7月1日 · Trophoblastic Cell Surface Antigen 2 (TROP-2) is a surface glycoprotein currently under study in advanced refractory NSCLC. TROP-2 is an attractive candidate for targeted …