Autoantibody mimicry of hormone action at the thyrotropin receptor
2022年8月8日 · Hypothalamic and pituitary sensing of low thyroid hormone levels induces secretion of the pituitary hormone thyrotropin—also called thyroid-stimulating hormone …
Nature｜ “push and pull”激活模型——TSH和抗体介导的TSHR激活
2022年9月27日 · TSHR 和相关的糖蛋白激素受体包含亮氨酸重复结构域 (LRRD)、铰链区和跨膜结构域 (TMD)。 其中，TSHR α亚基可以从β亚基中解离出来，成为抗原，进一步被免疫系统识 …
全面解析促甲状腺素受体（TSHR）：甲状腺疾病的诊断与治疗新 …
2024年7月22日 · 促甲状腺素受体（Thyrotropin receptor, TSHR）是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲 …
Modulating TSH Receptor Signaling for Therapeutic Benefit
In this review, novel pharmacological strategies with allosteric small-molecule modulators to treat GO and GD on the level of the TSHR and/or the TSHR/IGF-1R cross-interaction will be …
Current Loss-of-Function Mutations in the Thyrotropin Receptor …
2013年3月1日 · The TSHR ECD contains a leucine-rich region (LRR) involved in hormone binding specificity and two cysteine-rich domains that would contribute to the 3D structure of the ECD …
Hormone- and antibody-mediated activation of the thyrotropin
2022年8月8日 · Comparisons of the active and inactivated structures of TSHR with those of the luteinizing hormone/choriogonadotropin receptor (LHCGR) reveal a universal activation …
Rearrangement of the Extracellular Domain/Extracellular Loop 1 ...
2016年7月1日 · The thyroid stimulating hormone receptor (TSHR) is a G protein-coupled receptor (GPCR) with a characteristic large extracellular domain (ECD). TSHR activation is initiated by …
Glycoprotein hormone receptors: determinants in leucine-rich …
Glycoprotein hormone receptors [thyrotropin (TSHr), luteinizing hormone/chorionic gonadotropin (LH/CGr), follicle stimulating hormone (FSHr)] are rhodopsin-like G protein-coupled receptors …
The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid …
2009年6月1日 · The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and is also one of the major autoantigens for the autoimmune thyroid diseases. We …
Thyrotropin Receptor | SpringerLink
The TSHR is a large seven-transmembrane G-protein-coupled receptor that is made up of the ECD which contains the ligand-binding LRR and is connected to the TMD by the hinge region.
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