TSH Receptor Mutations and Diseases - Endotext - NCBI Bookshelf
2017年7月24日 · The thyroid-stimulating hormone (TSH) receptor (TSHR) is a member of the glycoprotein hormone receptors (GPHRs), a sub-group of class A G protein-coupled receptors …
Nature｜ “push and pull”激活模型——TSH和抗体介导的TSHR激活
2022年9月27日 · 该研究首次揭示了TSH与TSHR相互作用的细节模式，解析了TSH激活TSHR的分子机制，阐释了抗体激活或抑制受体从而引发甲状腺相关疾病的分子机制，为临床开发用于治 …
全面解析促甲状腺素受体（TSHR）：甲状腺疾病的诊断与治疗新 …
2024年7月22日 · 促甲状腺素受体（Thyrotropin receptor, TSHR）是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲 …
Hormone- and antibody-mediated activation of the thyrotropin
2022年8月8日 · Here we report the active structures of TSHR with TSH and the activating autoantibody M225, both bound to the allosteric agonist ML-1096, as well as an inactivated …
Novel Insights on Thyroid-Stimulating Hormone Receptor Signal ...
2022年4月13日 · The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors. The TSHR is of great importance for the …
Hormone- and antibody-mediated activation of the thyrotropin …
Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone-an essential metabolic hormone 1 …
TSHR thyroid stimulating hormone receptor [ (human)]
Data indicate the structural integrity of thyroid stimulating hormone receptor isoform (TSHR) and its potential binding of thyroid stimulating hormone (TSH). TSHR protein was detected on …
Nature：徐华强/蒋轶/张抒扬合作揭示自身免疫性甲亢甲减的分子 …
2022年8月10日 · 该项工作首次揭示了TSH与TSHR相互作用的细节模式，阐明了决定TSH和TSHR特异性识别的关键氨基酸残基，并揭示了TSH激活TSHR的分子机制，揭示了抗体激活 …
TSHR Gene - GeneCards | TSHR Protein | TSHR Antibody
2024年12月25日 · TSHR (Thyroid Stimulating Hormone Receptor) is a Protein Coding gene. Diseases associated with TSHR include Hyperthyroidism, Familial Gestational and …
RCSB PDB - 7XW5: TSHR-thyroid stimulating hormone-Gs-ML109 …
2022年8月24日 · Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone-an essential metabolic …