Thrombospondin-1 regulation of latent TGF-β activation: A …
In this review, we will discuss the role of the matricellular protein, thrombospondin 1 (TSP-1), in regulation of latent TGF-β activation and the use of an antagonist of TSP-1 mediated TGF-β activation in a number of diverse fibrotic diseases.
Thrombospondin-1 对潜在 TGF-β 激活的调节：纤维化疾病的治疗 …
In this review, we will discuss the role of the matricellular protein, thrombospondin 1 (TSP-1), in regulation of latent TGF-β activation and the use of an antagonist of TSP-1 mediated TGF-β activation in a number of diverse fibrotic diseases.
Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent …
Thrombospondin 1 (TSP1) plays major roles in both physiologic and pathologic tissue repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-β activation and plays a role in wound healing and fibrosis.
Activation of latent TGF-β by thrombospondin-1: mechanisms …
2000年4月1日 · We have identified a mechanism for the activation of latent TGF-β that involves binding of the secreted and extracellular matrix protein, thrombospondin-1 (TSP-1), to the latent precursor.
TGF-β activation by bone marrow-derived thrombospondin-1 …
2017年5月30日 · Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, TGF-β blockade can prevent...
血小板反应蛋白-1激活潜在的TGF-β：机制和生理 ... - X-MOL
2000年3月10日 · 认为tsp-1与潜伏复合物的结合以防止lap赋予tgf-β的成熟结构域潜伏期的方式诱导lap的构象重排。 TSP依赖的激活机制可能在伤口愈合过程中和在上皮结构的产后发育中很重要。
Thrombospondin-4 mediates TGF-β-induced angiogenesis
2017年5月8日 · We are describing a novel pathway that mediates induction of angiogenesis in response to TGF-β1. We found that in endothelial cells (EC) thrombospondin-4 (TSP-4), a secreted extracellular...
Transforming growth factor-β in stem cells and tissue homeostasis …
2018年1月31日 · Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis,...
Thrombospondin immune regulation and the kidney - PubMed
2017年7月1日 · Thrombospondins (TSPs) play an important role in activating TGF-β. In the healthy kidney, two TSPs are expressed, TSP1 and TSP2, which exert contrasting effects. While TSP1 is a major activator of TGF-β in renal cells and exerts pro-inflammatory effects both in vitro and in vivo, TSP2 lacks the ability for TGF-β activation but regulates ...
TSP-1、 TGF-β和PPAR-γ在脑胶质瘤中的表达及其与微血管密度的 …
目的 探讨凝血酶敏感蛋白-1 (TSP-1)、生长转化因子-β (TGF-β)和过氧化物酶体增殖物激活受体-γ (PPAR-γ)在脑胶质瘤中的表达及其与血管生成的关系。 方法 应用免疫组织化学法对62例胶质瘤组织中的TSP-1、TGF-β和PPAR-γ的表达及微血管密度 (MVD)进行检测。 结果...