2019年1月10日 · While specific binders to other variant repeat sequences have been lacking to date, we here identify ZBTB10 as the first TTGGGG-binding protein and demonstrate direct …

1989年1月26日 · The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA …

While specific binders to other variant repeat sequences have been lacking to date, we here identify ZBTB10 as the first TTGGGG-binding protein and demonstrate direct binding via the …

2023年3月1日 · ZBTB10 specifically interacts with the double-stranded telomeric variant repeat sequence TTGGGG by employing its tandem C2H2 zinc fingers (ZF1–2). Here, we solved the …

We have found a novel activity in Tetrahymena cell free extracts that adds tandem TTGGGG repeats onto synthetic telomere primers.

For vertebrates, the nucleotide sequence of telomeric DNA repeats is TTAGGG (G-strand), with the complementary strand being CCCTAA (C-strand). The G-strand is longer than the C …

1989年1月26日 · The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA …

2019年1月10日 · ZBTB10 is identified as the first TTGGGG-binding protein and direct binding via the two zinc fingers with affinity in the nanomolar range is demonstrated and establishes …

2019年1月10日 · Telomeres are nucleoprotein structures at the ends of linear chromosomes and present an essential feature for genome integrity. Vertebrate telomeres usually consist of …

We propose that the novel telomere terminal transferase is involved in the addition of telomeric repeats necessary for the replication of chromosome ends in eukaryotes. We have found a …